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@erictopol
physician-scientist, author of SUPER AGERS https://tinyurl.com/3w76us9a and Ground Truths: http://erictopol.substack.com
Science
The research focuses on genetic variants within gut bacteria, beyond the species and metabolites often discussed in connection with health.
Science
AutoDNA points toward an autonomous lab where human effort would be limited to hardware maintenance.
Science
Researchers analyzing ~2.8 million genomes identified 127 total genomic regions linked to Alzheimer's risk, including 48 newly discovered common loci—a ~60% increase. A high proportion point to microglia (brain immune cells) function, reinforcing immune and inflammation pathways.
Science
Columbia University reports that microscopy found fibers inside sperm cells, not just on their surfaces.
Science
A post says deleting the Piezo1 pressure-sensing receptor prevented that sensing and produced the opposite result.
Science
Cell says disrupting IFN-γ signaling in regulatory T cells reduced side effects without compromising antitumor immunity.
Science
Science reports Washington State University testers photographed 100 cannon-fired pitches at Petco Park for later camera calibration.
AI
Microsoft researchers report in Science that MAI-DxO scored 80.3% accuracy versus 46.8% for physicians on text-based emergency cases.
Science
Intismeran autogene targets mutations unique to each patient's tumor, STAT reports.
Science
Recent Nature coverage highlighted detailed mapping of a previously uncharacterized brain region and introduced a "personal health agent" research framework, with related X discussion on emerging diagnostics including pTau217 biomarker for Alzheimer's disease.
AI
OpenAI reports a DCTN1-cholesterol research lead from GPT-Rosalind agents working with Scripps Research.
Science
PerturbAI says biology experts preferred the multi-agent interpretations to single-agent reports in 75% of blinded comparisons.
Science
The Straits Times reports patients with the highest scores were more likely to die within 90 days.
Science
Provisional CDC data counted 694,708 heart disease deaths, about 1.6 percent more than in 2024.
AI
A post pairs the line “Our AI times :-)” with a link to a photo.
AI
A Science Translational Medicine paper describes two aging metrics drawn from plasma metabolomic profiles across the human life span.
Science
Science Translational Medicine says a large clinical study in China found aging ‘clocks’ that may predict chronic disease.
AI
Nature says the patterns are linked to disease and mortality and missed by conventional sleep measures.
Science
A post links to a JCI article on the risk of Wolff-Parkinson-White syndrome, a congenital heart arrhythmia.
Science
A post flags the variation and links to an article abstract in JAMA Neurology.
