Moderna and Merck’s personalized mRNA cancer vaccine reduced the risk of melanoma recurrence by 42% compared with a standard treatment in a large clinical trial, Adam Feuerstein reported for STAT on Oct. 22. That is a relative reduction in risk, not a 42-percentage-point drop in the recurrence rate. STAT described the detailed data as confirming that the trial met key endpoints, though its opening report does not name the precise standard-treatment arm or detail every endpoint.
The vaccine, called intismeran autogene, is individualized to attack mutations unique to a patient’s tumor, known as neoantigens, STAT reported. The outlet said oncologists called the results an advance because patients lived significantly longer without their cancer returning.
The published result is separate from earlier claims about how the data surfaced and an alleged move in Moderna’s shares. In an Oct. 22 post, Feuerstein said an ESMO embargo had lifted following a breach, without identifying who caused it. Earlier, epictrades1 claimed, citing The Wall Street Journal, that OncologyCentral appeared to publish the study ahead of its release. ttvresearch claimed Moderna was trading nearly 20% lower following an alleged early release of data. Those posts do not establish the source of the breach or verify the size or cause of a share move.