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Phase 3 trial: Adding Moderna-Merck mRNA treatment to pembrolizumab cut recurrence-or-death risk 42% after high-risk melanoma surgery

The 1,137-patient study tested personalized treatment intismeran alongside pembrolizumab after surgery for high-risk melanoma.

2 Sources, 2h ago, updated 2h ago

Science

48 new Alzheimer's risk loci identified in landmark Nature study of 2.8 million genomes

Researchers analyzing ~2.8 million genomes identified 127 total genomic regions linked to Alzheimer's risk, including 48 newly discovered common loci—a ~60% increase. A high proportion point to microglia (brain immune cells) function, reinforcing immune and inflammation pathways.

3 Sources, 1d ago, updated 1d ago

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Phase 3 trial: Adding Moderna-Merck mRNA treatment to pembrolizumab cut recurrence-or-death risk 42% after high-risk melanoma surgery

48 new Alzheimer's risk loci identified in landmark Nature study of 2.8 million genomes

Featured in

Phase 3 trial: Adding Moderna-Merck mRNA treatment to pembrolizumab cut recurrence-or-death risk 42% after high-risk melanoma surgery

48 new Alzheimer's risk loci identified in landmark Nature study of 2.8 million genomes