Experimental model links dietary and microbial changes to cancer immunotherapy side effects

Cell describes dietary and microbial changes as increasing susceptibility to immune checkpoint therapy side effects by making regulatory T cells fragile and promoting inflammatory immune responses. It says disrupting IFN-γ signaling in those cells reduced side effects without compromising antitumor immunity. Medical Xpress reports that blocking a protein in unstable immune cells reversed immunotherapy-linked inflammation in mice, and that similar cell fragility was seen in patients with severe side effects.