Science Advances

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Science Advances is an open-access multidisciplinary journal, publishing impactful research papers and reviews in any area of science.

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'Progenitor Cell Ark' designed for cell delivery and multi-level repair

Science Advances describes the researchers’ design as a triple-layered hydrogel microsphere system.

2 Sources, 7d ago, first seen 7d ago

Optical microscopy of a hydrogel microsphere loaded with nucleus pulposus progenitor cells. Credit: Yinlin Yang

Science

Machine learning-assisted evolution of tobacco Rubisco could improve crop productivity

Science Advances says a new study engineers tobacco Rubisco for improved carboxylic acid creation efficiency.

1 Source, 10d ago, first seen 10d ago

Science

Jonathan the 194-year-old giant tortoise is helping researchers study extreme longevity

A Science Advances study says researchers sequenced the genome and methylome of Jonathan, an Aldabra giant tortoise that Science Advances described as the oldest known living land animal, to look for genetic and epigenetic clues to his lifespan.

12 Sources, 10d ago, updated 10d ago

Dorsal scute of an Aldabra giant tortoise shell. Recent longevity studies have used comparative genomic analysis to reveal gene markers with the potential to slow aging and inhibit cancer in long-lived species. Vaisvil et al. report the first genome sequence of the 194-year-old Aldabra giant tortoise Jonathan, the oldest known living land animal. DNA methylome analysis showed that comparatively lower-entropy regions in Jonathan’s methylome were linked to higher-fidelity gene transcription and more efficient DNA repair, energy production, and RNA processing. These findings support a model for aging where efficient energy production supports robust DNA repair, thus preserving genomic integrity and potentially contributing to improved longevity.

Credit: Stephen Clark

Science

A speech clock aims to track biological aging and dementia markers from voice

Science Advances says the tool draws on data from 2,928 people across five Latin American countries.

4 Sources, 15d ago, updated 15d ago

Science

Tibetan Plateau ice-core record indicates Guliya ice cap is over 100,000 years old

Science Advances says researchers constructed the oldest ice-core-derived climate record from the Tibetan Plateau.

2 Sources, 21d ago, first seen 21d ago

The Guliya ice cap (GIC) is the largest body of ice in the western Kunlun Mountains in the Tibetan Plateau. Ice cores drilled on the GIC preserve the record of past climate change in the region, an area which provides water for several billion people in Central and South Asia. Thompson et al. analyzed ice cores drilled in 1992 and 2015 and used cosmogenic isotopes and Asian monsoon records to construct an accurate climate timescale extending back 128,000 years, the oldest ice-core-derived climate record from the Tibetan Plateau. The timeline supports the presence of glacial-stage ice in the GIC, confirming that GIC ice is over 100,000 years old.

Credit: Lonnie G. Thompson

Featured in

'Progenitor Cell Ark' designed for cell delivery and multi-level repair

Machine learning-assisted evolution of tobacco Rubisco could improve crop productivity

Jonathan the 194-year-old giant tortoise is helping researchers study extreme longevity

A speech clock aims to track biological aging and dementia markers from voice

Tibetan Plateau ice-core record indicates Guliya ice cap is over 100,000 years old

Featured in

'Progenitor Cell Ark' designed for cell delivery and multi-level repair

Machine learning-assisted evolution of tobacco Rubisco could improve crop productivity

Jonathan the 194-year-old giant tortoise is helping researchers study extreme longevity

A speech clock aims to track biological aging and dementia markers from voice

Tibetan Plateau ice-core record indicates Guliya ice cap is over 100,000 years old