ScienceBlood DNA patterns may flag breast and prostate cancer risk up to eight years before diagnosis
A study in Cell Genomics reports that cell-free DNA methylation patterns distinguish future prostate cancer risk levels. Breast cancer signals were modest and varied by subtype and other factors.
TLDR
Researchers writing in Cell Genomics examined methylation patterns in cell-free DNA from archived blood plasma collected two weeks to nine years before breast or prostate cancer diagnosis. The paper describes early risk signatures up to eight years before clinical detection. Patterns in DNA regulatory regions distinguished future prostate cancer risk, while breast cancer signals were modest and varied by subtype, mammography interval and progression to metastatic disease.
Blood DNA patterns may flag breast and prostate cancer risk up to eight years before diagnosis
A study in Cell Genomics reports that cell-free DNA methylation patterns distinguish future prostate cancer risk levels. Breast cancer signals were modest and varied by subtype and other factors.
TLDR
Researchers writing in Cell Genomics examined methylation patterns in cell-free DNA from archived blood plasma collected two weeks to nine years before breast or prostate cancer diagnosis. The paper describes early risk signatures up to eight years before clinical detection. Patterns in DNA regulatory regions distinguished future prostate cancer risk, while breast cancer signals were modest and varied by subtype, mammography interval and progression to metastatic disease.