Indole-producing gut E. coli may worsen ischemic stroke through immune-cell signaling
A Cell paper says indole-producing E. coli worsens ischemic stroke by activating AHR signaling in dendritic cells.
TLDR
A Cell paper says indole-producing E. coli worsens ischemic stroke through AHR signaling in dendritic cells. It says limiting that signaling promotes the movement of gut-derived dendritic cells to the meninges, expands regulatory T cells there and reduces neuroinflammation. The paper identifies the pathway as a potential treatment target.
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