Nature Biotechnology

@naturebiotech

Publishing the best of biotech science and business. Find us on Bluesky, Facebook & Instagram. Part of @SpringerNature and @NaturePortfolio.

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New calibration framework reportedly improves confidence in AI virtual cell models

GEN reports that the authors say mean squared error and control-referenced Pearson correlation are frequently miscalibrated.

1 Source, 7d ago, first seen 7d ago

Science

FDA approves Rasonque, a first-in-class RAS inhibitor for pancreatic cancer

Nature Biotechnology reports that an early-stage trial also suggests the drug has promise in lung cancer.

1 Source, 7d ago, first seen 7d ago

Science

Ligand-directed lipid nanoparticles for engineering CAR natural killer cells in vivo

Nature Biotechnology shares a paper on engineering CAR natural killer cells inside the body for immunotherapy.

1 Source, 8d ago, first seen 8d ago

Science

Nature Biotechnology's October cover depicts engineered inhalable exosomes

Nature Biotechnology says the exosomes display a bispecific T cell activator targeting a cancer cell and a T cell.

1 Source, 8d ago, first seen 8d ago

Science

Bird-derived jumping gene reportedly rewritten to insert DNA into human cells with RNA alone

NatureBiotech shares a Scienmag story whose headline describes the rewritten jumping gene as using RNA alone.

1 Source, 8d ago, first seen 8d ago

Science

Scientists reportedly find a way to make RNA vaccines survive higher temperatures

NatureBiotech linked to a Yahoo News story saying scientists found a way to make RNA vaccines survive higher temperatures.

2 Sources, 6d ago, updated 6d ago

Science

Drug discovery in Q3 2026: AI, virtual screening and molecular glues

Drug Target Review examines these developments alongside human-relevant models and what to watch heading into Q4.

1 Source, 14d ago, first seen 14d ago

Science

Deep-learning perturbation models can outperform baselines on calibrated metrics

Nature Biotechnology also linked to Shift Bioscience’s claim that its publication builds confidence in AI virtual cells for novel target discovery.

1 Source, 14d ago, first seen 14d ago

Science

Retinal-image AI predicted preeclampsia before diagnosis in a two-site study

A Nature Biotechnology paper reports an AUC of 0.81 for Visionary AI in a 66-person NYU validation group.

1 Source, 15d ago, first seen 15d ago

Science

Nobel Prize in Medicine awarded to Deisseroth, Hegemann and Nagel

Nature says the prize recognizes their discoveries concerning light-gated ion channels and optogenetics.

科学

101 Sources, 10d ago, updated 10d ago

Science

Deep learning perturbation models can outperform baselines on calibrated metrics

Nature Biotechnology says the finding comes from a calibration-aware evaluation of perturbation models.

1 Source, 20d ago, first seen 20d ago

Science

Transient TALE-based editor expression demonstrates durable silencing in non-human primates

Separately, Nature Biotechnology says optimized regulators made sustained epigenetic silencing in monkeys more efficient.

1 Source, 20d ago, first seen 20d ago

Science

Manipulating RNA condensates can control stem cell differentiation

Nature Biotechnology reports that selectively sequestering RNA in biomolecular condensates directs changes in cell fate.

1 Source, 21d ago, first seen 21d ago

Science

Engineered bacteria for on-demand blood sugar control

Nature Biotechnology shared a research highlight titled “On-demand glycemic control by engineered bacteria.”

1 Source, 22d ago, first seen 22d ago

Science

Genetic toolkit may improve studies of gut bacteria’s role in disease

Northwestern University reports that the toolkit could help researchers investigate how Clostridia bacteria in the gut contribute to disease.

1 Source, 22d ago, first seen 22d ago

Science

DIAL designs synthetic promoters for heritable gene-expression setpoints

Nature Biotechnology describes the work as programmable promoter editing for precise control of transgene expression.

1 Source, 22d ago, first seen 22d ago

Science

Scientists uncover thousands of previously missed proteins, including potential cancer immunotherapy targets

Nature Biotechnology reports that many of the proteins appear relevant to human health. Its story focuses on startups mining the “dark proteome” for drug targets.

1 Source, 23d ago, first seen 23d ago

Science

Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing

Nature Biotechnology describes lipid nanoparticles improved by accounting for RNA cargo size during design.

2 Sources, 21d ago, updated 21d ago

Science

Data-efficient AI accelerates discovery of thermostable mRNA–lipid nanoparticle vaccines

Nature Biotechnology says AI improved the thermostability of RNA vaccines.

2 Sources, 22d ago, updated 22d ago

Science

Light-sensitive molecules reportedly enable spatially resolved single-cell measurements

Nature Biotechnology describes a light-sensitive oligonucleotide system for studying how the epigenome regulates gene expression, using measurements of individual cells in spatial context.

1 Source, 26d ago, first seen 26d ago

Featured in

New calibration framework reportedly improves confidence in AI virtual cell models

FDA approves Rasonque, a first-in-class RAS inhibitor for pancreatic cancer

Ligand-directed lipid nanoparticles for engineering CAR natural killer cells in vivo

Nature Biotechnology's October cover depicts engineered inhalable exosomes

Bird-derived jumping gene reportedly rewritten to insert DNA into human cells with RNA alone

Scientists reportedly find a way to make RNA vaccines survive higher temperatures

Drug discovery in Q3 2026: AI, virtual screening and molecular glues

Deep-learning perturbation models can outperform baselines on calibrated metrics

Retinal-image AI predicted preeclampsia before diagnosis in a two-site study

Nobel Prize in Medicine awarded to Deisseroth, Hegemann and Nagel

Deep learning perturbation models can outperform baselines on calibrated metrics

Transient TALE-based editor expression demonstrates durable silencing in non-human primates

Manipulating RNA condensates can control stem cell differentiation

Engineered bacteria for on-demand blood sugar control

Genetic toolkit may improve studies of gut bacteria’s role in disease

DIAL designs synthetic promoters for heritable gene-expression setpoints

Scientists uncover thousands of previously missed proteins, including potential cancer immunotherapy targets

Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing

Data-efficient AI accelerates discovery of thermostable mRNA–lipid nanoparticle vaccines

Light-sensitive molecules reportedly enable spatially resolved single-cell measurements

Featured in

New calibration framework reportedly improves confidence in AI virtual cell models

FDA approves Rasonque, a first-in-class RAS inhibitor for pancreatic cancer

Ligand-directed lipid nanoparticles for engineering CAR natural killer cells in vivo

Nature Biotechnology's October cover depicts engineered inhalable exosomes

Bird-derived jumping gene reportedly rewritten to insert DNA into human cells with RNA alone

Scientists reportedly find a way to make RNA vaccines survive higher temperatures

Drug discovery in Q3 2026: AI, virtual screening and molecular glues

Deep-learning perturbation models can outperform baselines on calibrated metrics

Retinal-image AI predicted preeclampsia before diagnosis in a two-site study

Nobel Prize in Medicine awarded to Deisseroth, Hegemann and Nagel

Deep learning perturbation models can outperform baselines on calibrated metrics

Transient TALE-based editor expression demonstrates durable silencing in non-human primates

Manipulating RNA condensates can control stem cell differentiation

Engineered bacteria for on-demand blood sugar control

Genetic toolkit may improve studies of gut bacteria’s role in disease

DIAL designs synthetic promoters for heritable gene-expression setpoints

Scientists uncover thousands of previously missed proteins, including potential cancer immunotherapy targets

Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing

Data-efficient AI accelerates discovery of thermostable mRNA–lipid nanoparticle vaccines

Light-sensitive molecules reportedly enable spatially resolved single-cell measurements