ScienceAPOE4-linked changes in brain blood vessels and a potential way to reverse them
A Cell study reports that APOE4 drives a cell transition that promotes blood-vessel scarring and amyloid buildup. Blocking TGF-β reversed that remodeling, the study reports.
TLDR
The study in Cell links APOE4 to a transition from pericytes to myofibroblasts that promotes scarring of brain blood vessels and amyloid accumulation around them. The researchers report that inhibiting TGF-β reverses this remodeling, presenting it as a potential therapeutic strategy.
APOE4-linked changes in brain blood vessels and a potential way to reverse them
A Cell study reports that APOE4 drives a cell transition that promotes blood-vessel scarring and amyloid buildup. Blocking TGF-β reversed that remodeling, the study reports.
TLDR
The study in Cell links APOE4 to a transition from pericytes to myofibroblasts that promotes scarring of brain blood vessels and amyloid accumulation around them. The researchers report that inhibiting TGF-β reverses this remodeling, presenting it as a potential therapeutic strategy.
