Metformin's low-dose blood sugar effects linked to a brain Rap1 pathway

A post describes a 2025 Science Advances study led by Baylor College of Medicine scientists that links metformin's low-dose effects to Rap1 in the brain. According to the post, neurons involved in the pathway respond to doses thousands of times smaller than those needed to affect peripheral organs. The author suggests the finding could inform future treatments aimed at slowing brain aging and cognitive decline.