Skull marrow immune cells may fuel inflammation in chronic traumatic brain injury

Researchers writing in Science Translational Medicine report that chronic traumatic brain injury changes immune-cell production in skull bone marrow. Inflammatory cells from the marrow then enter the brain and contribute to ongoing inflammation and neurological deficits. In a proof-of-concept randomized trial of 40 older adults with chronic traumatic brain injury, fenofibrate lowered plasma neurofilament light chain levels and improved cognitive function, suggesting a potential treatment.