Girdin-L protein linked to the breakdown of primary cilia on cells
Science reports that Girdin-L binds to a region of the Dishevelled protein called the PDZ domain and plays an important role in promoting primary cilia breakdown.
TLDR
Science reports that proximity labeling and biophysical analysis identified Girdin-L as an unexpected binding partner for the PDZ domain of Dishevelled. The research describes an unusual binding mode through which Dishevelled drives the disassembly of primary cilia on cells.
Girdin-L protein linked to the breakdown of primary cilia on cells
Science reports that Girdin-L binds to a region of the Dishevelled protein called the PDZ domain and plays an important role in promoting primary cilia breakdown.
TLDR
Science reports that proximity labeling and biophysical analysis identified Girdin-L as an unexpected binding partner for the PDZ domain of Dishevelled. The research describes an unusual binding mode through which Dishevelled drives the disassembly of primary cilia on cells.
