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First reported addition of a gene to a cephalopod yields cuttlefish that glow red under fluorescent light

Science reports the fluorescent-protein gene is present even in the cuttlefish’s eggs and sperm, and their offspring glow too.

Science MagazineSM
1 Source, 1h ago, first seen 1h ago

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Science reports that Columbia University neuroscientist Tessa Montague produced seven cuttlefish that glow red under fluorescent light after six years and thousands of embryos. The synthetic fluorescent-protein gene is in every cell, including eggs and sperm, and their offspring glow too. The work, posted as a preprint, is described as the first successful addition of a new gene to a cephalopod. Montague hopes to make neurons fluoresce as they fire to study how cuttlefish brains control camouflage.

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1 Source, first seen 1h ago

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Combined views

6K

1 Source, first seen 1h ago

25 likes3 comments6 saves4 reposts
Scientists engineered a glowing cuttlefish. Why was it so hard?

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Science Magazine@ScienceMagazineExclusive: When Tessa Montague learned about #CRISPR, the gene-editing system that was supposed to make it easy to modify any organism, she set her sights on the cuttlefish. The Columbia University neuroscientist dreamed of injecting its embryos with genes that would prompt its neurons to fluoresce as they fired. The flashes would let her track how this tentacled creature's brain controls one of its most striking behaviors: camouflaging itself by copying patterns it perceives in its surroundings onto its skin. Unlike most animals, she says, “cuttlefish can actually tell us what they see.” Six years and thousands of embryos later, she has reached a milestone: seven cuttlefish that glow red under fluorescent light. Every cell in their boneless bodies contains a gene encoding a synthetic fluorescent protein—even their eggs and sperm, which means their cuttlebabies glow, too. The work, posted as a preprint, marks the first time anyone has successfully added a new gene to a cephalopod. https://scim.ag/4ytddWd @NewsfromScience1h
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    Science Magazine@ScienceMagazineExclusive: When Tessa Montague learned about #CRISPR, the gene-editing system that was supposed to make it easy to modify any organism, she set her sights on the cuttlefish. The Columbia University neuroscientist dreamed of injecting its embryos with genes that would prompt its neurons to fluoresce as they fired. The flashes would let her track how this tentacled creature's brain controls one of its most striking behaviors: camouflaging itself by copying patterns it perceives in its surroundings onto its skin. Unlike most animals, she says, “cuttlefish can actually tell us what they see.” Six years and thousands of embryos later, she has reached a milestone: seven cuttlefish that glow red under fluorescent light. Every cell in their boneless bodies contains a gene encoding a synthetic fluorescent protein—even their eggs and sperm, which means their cuttlebabies glow, too. The work, posted as a preprint, marks the first time anyone has successfully added a new gene to a cephalopod. https://scim.ag/4ytddWd @NewsfromScience1h
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