RGS4 helps sustain chronic pain-related hypersensitivity in mice

Science Signaling reports that RGS4 in the dorsal root ganglia helps maintain chronic pain-related hypersensitivity in mice. Deleting Rgs4 in certain sensory nerve fibers reduced hypersensitivity without affecting acute pain responses. The findings may inform the development of precision drugs targeting pain-related GPCR signaling.