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How the loss of cell identity fits into aging
Writing in Ground Truths, Eric Topol argues that aging is not just accumulated damage. He points to a Nature review and earlier work that put the loss of cell identity at the center of the explanation.
TLDR
Eric Topol argues that aging involves more than wear and tear: the loss of cell identity takes center stage. The Nature paper he cites describes mammalian aging in terms of cell identity becoming less stable as a regulatory “grammar” written during development erodes.
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