Anshul Kundaje#1675
Today, we’re excited to share mRNAutilus, our experimentally-validated framework for multi-objective generation of full-length mRNAs, jointly optimizing coding sequences and UTRs for expression, stability, and translation!⚓️
📜: https://arxiv.org/abs/2605.31296 💻: https://autona.atombio.ai/
Super happy to finally share mRNAutilus 🧬, our wet-lab-validated generative model for mRNA therapeutic design with multi-objective guidance for half-life, translation efficacy, and protein abundance!
📃 Paper: https://arxiv.org/abs/2605.31296 🔮 Project Page: https://mrna-multi-objective-design.github.io/ 🖋️ Blog Post: https://alchemybio.substack.com/p/mrna-multi-objective-design 💻 Interface: https://autona.atombio.ai/home
This project feels super special because it builds on one of my first algorithms, Monte Carlo Tree Guidance from PepTune, and shows that it works in vitro for real, therapeutically relevant tasks! 🌟
More details in the thread 👇🏻
Anshul Kundaje#1675Today, we’re excited to share mRNAutilus, our experimentally-validated framework for multi-objective generation of full-length mRNAs, jointly optimizing coding sequences and UTRs for expression, stability, and translation!⚓️
📜: https://arxiv.org/abs/2605.31296 💻: https://autona.atombio.ai/
Users are praising the mRNAutilus framework for optimized mRNA design and the researchers' lab work because they see it as groundbreaking and appreciate the contributions.