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    AI-designed rentosertib slowed six protein-based aging clocks in a small trial, a post says

    Nature Biotechnology describes a phase 2a clinical trial using six proteomic aging clocks to assess anti-aging effects.

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    1 Source, 23d ago, first seen 23d ago

    TLDR

    Rentosertib, an AI-designed anti-fibrotic drug still in development, showed slowing across all six proteomic, or protein-based, aging clocks in a small trial, according to a post sharing a Nature Biotechnology paper. The post calls it the first drug in development to show slowing of proteomic aging clocks. Nature Biotechnology describes the work as a phase 2a trial using six such clocks to assess anti-aging effects.

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    1 Source, first seen 23d ago

    Combined views

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    1 Source, first seen 23d ago

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    23 comments
    173 saves
    83 reposts

    Sentiment

    Positive——Negative

    Summary

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    No sentiment analysis available yet.

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    1 Source

    @EricTopolThe first drug in development (rentosertib, anti-fibrotic, designed with AI) to show slowing of proteomic aging clocks, 6 of 6, in a small trial @gladyshev_lab @NatureBiotech @biogerontology @InSilicoMeds https://www.nature.com/articles/s41587-026-03286-y

    1 Source

    @EricTopolThe first drug in development (rentosertib, anti-fibrotic, designed with AI) to show slowing of proteomic aging clocks, 6 of 6, in a small trial @gladyshev_lab @NatureBiotech @biogerontology @InSilicoMeds https://www.nature.com/articles/s41587-026-03286-y