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52 Comments
- dirtyfratboy, on 10/12/2007, -1/+19Why isn't this getting a huge influx of diggs? Unless this is a hoax, this is pretty big news!
IMO, more worthy of the frontpage than many other current submissions, including my own. - FiReaNG3L, on 10/12/2007, -1/+15I can understand how some diggers can get frustrated by the medical 'revelations' seen on digg; some of them are really wildly inaccurate and irrelevant. However, some of them, such as this one, are scientific revelations that may lead to medical treatments, or at least significantly improve our understanding of the problem (in this case, HIV).
The paper was published in PNAS (Proceedings of the National Academy of Sciences), a renowned journal, and has been reviewed by peers prior to publication. Still, has you said, its just one study. But I personally work in the field, and I say its damn interesting! - theone3, on 10/12/2007, -3/+11Perhaps it's because people are sick of daily medical 'revelations' that lead to absolutely no results. Most of these reports are wildly inaccurate and I'd be willing to bet this article is no different. After all, it's only one study right now. It needs real scientific confirmation from at least 20 others before most sit up and take notice.
- reiggin, on 10/12/2007, -9/+17Somebody forgot to tell the cells around the anal cavity.
- lateralus, on 10/12/2007, -6/+13"Job Done." = "Mission Accompllished"
Idiot.
You forgot to mention the whole "try not to get raped by Nigerian mob with machete` knives" or "try not to be born to HIV+ mother".
Thanks for your efforts though. Now we can put you back on the atom-splitting project. - dimatt, on 10/12/2007, -1/+7Yeah, I cant believe that some stories never actually make it to the front page sometimes.
- T0PS3O, on 10/12/2007, -4/+9Because in fact it's nothing new. Healthy cells can fight off pretty much anything nature throws at them. Too bad hardly anyone nowadays is truly healthy and besides natural hazardz, we also chuck chemicals and what not at our bodies. Not ot mention your new wireless router causing your cells some upset.
People have been successfully doing fasts for decades in order to restore full cell functionality. Cancer can be cured that way so I'm not surprised our cells were originally able to vend off HIV as well.
Read some books by Dr Bernard Jensen if this stuff interests you. - jrkaisersr, on 10/12/2007, -0/+5Black plague is a bacteria (Yersinia pestis), HIV is a virus. So Black Plague could not be a form of HIV. They do damage in two different ways.
- chiller2002, on 10/12/2007, -3/+7"Better still... ABSTINENCE! (I dare the sluts to digg this down!)"
Many worldwide infections occur due to rape, mostly due to the misconception that sex with a virgin "cures" HIV. Last time I checked, a 11 y/o virgin wasn't traditionally called a "slut". - Hoornet, on 10/12/2007, -2/+6This is a classic. Scientists are realizing the potential body power to heal itself. They will just have to learn how to help the body. That's all IMHO.
- primehifi, on 10/12/2007, -7/+10We're so close. Eventually,we can go back to having sex with monkeys. Thank God. I cannot wait to have sex with a monkey again. Oh the agony.
- B0jangles, on 10/12/2007, -4/+6Use a condom, sterilise your needles and never leave your wounds open. Job done.
- ViperDaimao, on 10/12/2007, -0/+2While your replies are technically correct, I believe the OP was talking about the avg western male or female. Your counters of "what if you get raped by a nigerian mob" or "whatif you were born with it" while true, are but a tiny percentage of how the virus is spread in the 1st world.
- bradbeattie, on 10/12/2007, -3/+4While this is cool, where's the cure? Over the past several years I've read stories like this. "We've discovered/developed something that might lead to a cure." When an actual cure is developed, I'll put my digg in then.
- ForbesBingley, on 10/12/2007, -1/+2I watched something of telly about this some years ago.
There's a gay guy in New York who's immune to all strains of AIDS and his descendants came from a village Derbyshire, England.
His descendants were among those who not only survived the initial plague, but who also didn't get the full-blown effects... - sk545, on 10/12/2007, -0/+1why is it that our cells can't mutate like the virus and adapt to kill organisms they normally can't? Why is it that viruses can mutate only? How fast do cells reproduce? Shouldn't they evolve much faster than humans?
- chiller2002, on 10/12/2007, -0/+1I think they were trying to point out that condoms, sterilized needles, and covered wounds isn't the end all solution as indicated by "Job Done.". Hence, the reference to Bush's "Mission Accomplished" -- which we all know isn't really quite a finished job. While you may be correct that the percentage isn't great in "1st world" countries, it doesn't mean that we can ignore the rest of the world. To be back on topic, the article is about finding a cure/vaccine/treatment for HIV, which is a very good thing, using a natural defense. While safer sex is very important, it doesn't help the rest of the world.
Sex != Slut - Lynxpro, on 10/12/2007, -0/+1Anybody know what the status is on using the mutated CCR5 gene to combat HIV/Aids? The last time I checked, a company was trying to patent the mutated gene that blocks HIV(1, I believe) infection in 10%-25% of all European descended peoples (and one discovered group of Chinese).
I'm still sticking with my insane theory that if you aren't lactose intollerant, you won't get HIV, since the consumption of dairy product is pretty much the cultural exclusive of Europeans and the idea that the CCR5 gene mutated in response to the Black Plague doesn't really make sense since the plague has hit just about every group of humanity throughout the ages at one point and thus more groups than just Europeans should have the mutant CCR5 gene. :) - tsunamisteve, on 10/12/2007, -4/+5In an evolution class I'm in, we recently watched a video detailing the evolution of viruses and mutations (meaning simply uncommon genetic variations) in cells that fight them, allowing natural selection to work. The genetic mutation that prevents HIV in some people actually dates back (through some magical DNA science) to the Black plague. I wish I still had access to the video, as it quite interesting. Essentially they proposed that the Black Plague was some flavor of HIV, and the people that survived it had mutated genes that didn't have the receptors used by HIV to infect and spread. Of course, right after the the Black Plague, the number of people in Europe with this mutation was proportionally very high, but has since lost such dominance over time.
- definiteform, on 10/12/2007, -2/+3Hopefully this can be implemented in a cost effective way to combat HIV.
- myxyplik, on 10/12/2007, -2/+3My comment was aimed at the morons who do nothing but watch MTV or "The O.C." and think that casual sex is the norm in society. My apologies if I came across as insensitive.
- ForbesBingley, on 10/12/2007, -0/+1"Yeah, I cant believe that some stories never actually make it to the front page sometimes."
That's the illogical process of Diggmocracy in action for you.
Enjoy... - inactive, on 10/12/2007, -0/+1A single infected T cell can produce thousands of virus particles. If all of those particles have a single mutation that renders them "dead" or unable to reinfect another T cell it does not matter because one of the other thousands of T cells will probably produce a viable virus or one with a mutation that makes the virus more fit. The virus can afford to mess itself up with mutations because there are millions of them in your body and only a few need to be fit enough to reinfect another cell. Now your cells do not have that luxury. If a single T cell were to gain a bad mutation you could end up with lymphoma. Our cells have a very robust virtually error free method of replication so mutations rarely happen (if they do the cell usually detects it and dies before anything bad happens). The HIV virus is the opposite. It replicates in a very error prone way and a such randomly arrives at mutations that make it more fit, are able to bypass protease inhibitors and other drugs over time.
Be sure to follow the links from saska above for a more indepth (better) explination. - ssquire, on 10/12/2007, -0/+1Better yet, stop it before it can replicate:
http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html - reiggin, on 10/12/2007, -0/+1So what you're saying is that there really IS a pot of gold at the end of the rainbow (ribbons)?
- GiggleStick, on 10/12/2007, -2/+3It's the ribbons people! The ribbons are stopping the virus! I knew it would work eventually.
- saska, on 10/12/2007, -0/+1I could spend an hour answering those four questions, or you could spend an hour reading here http://hivinsite.ucsf.edu/hiv?page=FAQ and here http://en.wikipedia.org/wiki/HIV
In short: They can mutate. Viruses aren't the only things that mutate. It depends on what kind of cell it is and under what conditions. Why should they? - tastypastry, on 10/12/2007, -1/+2[Bill Hicks]:
I've got material planned, I didn't say I'd take ***** requests. OK? I said if you wanted to hear it, I'd stay, I'm not a jukebox. I dunno how much AIDS scare y'all, but I got a theory - the day they come out with a cure for AIDS. Guaranteed, one-shot cure. On that day, there's gonna be ***** in the streets, man. It's over! Who're you? C'mere! What's your name, baby? No, it's over, yeah, woo-hoo! Man, if you can't get laid on that day, cut it off. - tsunamisteve, on 10/12/2007, -0/+1Perhaps it wasn't the black plague and was some other virus. I failed my last test in that class. :
- saska, on 10/12/2007, -0/+1....
You seem to misunderstand what random mutation means in the course of an ordered biological system.
When our cells mutate and they survive, and/or the body fails to eliminate them, do you know what it is called? Cancer. - sk545, on 10/12/2007, -0/+1"The HIV virus is the opposite. It replicates in a very error prone way and a such randomly arrives at mutations that make it more fit, are able to bypass protease inhibitors and other drugs over time."
Heh, guess our cells aren't "fit" then. Its like the virus is cool enough to mutate and live, while our cells just self destruct when a change occurs or is needed. Weird. Its like they are not able to evolve. - bonoes, on 10/12/2007, -1/+1Should I wear protection before downloading that?
- inactive, on 10/12/2007, -0/+0An interesting side, a good portion of our genome consist of ancient retroviral DNA that has integrated. It is likely that much of our ancient evolution (apologies to those who do not like this word) was brought about by genes gained from other viruses. Not to mention that mitochondria (the organelles in cells responsible for the conversion of glucose into ATP (cellular energy)) were likely bacteria that somehow incorporated into some early cellular life (they have their own DNA and protein set).
Don't forget to read chapter 6 for class tomorrow and I will see you all on Friday. - green67, on 10/12/2007, -0/+0well..I for one am forever hope full for a cure....if you've ever watched a loved one be taken by this horrible disease..you'd understand how important it is...how important ANY progress is....I'm not putting it above the big "c" or any other potentially fatal diseases....and I never will..I've lost people to other diseases as well..but...I feel this digg has gone off on a tangent...it's no place for smart ass comments...not about something so serious....come on people...show some humanity.
- inactive, on 10/12/2007, -0/+0HIV replicates in and kills T cells and Macrophages (and sometimes Dendritic cells).
As T cell numbers decrease so does the immune systems ability to fight certain diseases.
You eventually become immunodeficient (AIDS) and die.
I do not see how these facts are in doubt and how people can still say that HIV is not the cause of AIDS.
People who die from AIDS are infected with the HIV virus, it is a very strong correlation. - ForbesBingley, on 10/12/2007, -2/+2I'm all for the laying on of hands .. especially with my girlfriend.
I keep telling her, I've got an unusual swelling in my groin .. but does she listen? - alphageek101, on 10/12/2007, -4/+4I'm in medicine and I don't find these constant "one more new thing about AIDS" stories that newsworthy. People are constantly researching AIDS and cellular defense mechanisms. Why do we have to digg every pseudo breakthrough?
- ccran, on 10/12/2007, -0/+0@Bioman
HIV does not kill T-cells. No retrovirus kills its host cell. That's how they function.
"People who die from AIDS are infected with the HIV virus, it is a very strong correlation. "
Not a surprising correlation when the definition of AIDS is 29+ previously known diseases with the presence of HIV infection. - myxyplik, on 10/12/2007, -0/+0Yep, -3 diggs for my original reply. What has this world come to? *shakes head*
- inactive, on 10/12/2007, -1/+1Obviously, concidering HIV is a retrovirus.
Check this torrent out: http://isohunt.com/download.php?mode=bt&id=9277923 - EnricoFermi, on 10/12/2007, -0/+0Even if this study does end up leading to a cure it won't help the 30 million people in Africa suffering. Greedy ass pharmaceutical company's are gonna charge an arm and a leg for it. Only the 2 million or so HIV positive people in north America and Europe will benefit. So big whoop.
- B0jangles, on 10/12/2007, -1/+1'Job Done' does not equal 'Mission Accomplished'
What a small little world you live in. - harpdog, on 10/12/2007, -1/+1Does anyone remember what Bill Hicks said what would happen when they find a cure for aids?
- koguma, on 10/12/2007, -1/+1Guess what eating lots of spirulina every day blocks ALL VIRUSES from entering your cells. So what's the news? Spirulina was used on the children of Chernobyl to combat the effects of radiation poisoning.
http://www.spirulinasource.com/earthfoodch4b.html - ForbesBingley, on 10/12/2007, -3/+2Funny, but really crass...
- inactive, on 10/12/2007, -2/+1heheh, yeah its the pink ones that really do it. =D
- SWCarson, on 10/12/2007, -1/+0There may not even be an HIV/AIDS connection: Why I Quit HIV by Rebecca V. Culshaw http://www.lewrockwell.com/orig7/culshaw1.html
She writes: "Why have we as a society been so quick to accept a theory for which so little solid evidence exists?... The average citizen has no idea how weak the connection really is between HIV and AIDS, and this is the manner in which scientifically insupportable phrases like "the AIDS virus" or "an AIDS test" have become part of the common vernacular despite no evidence for their accuracy." - inactive, on 10/12/2007, -8/+5Cells have a natural defence against AIDS?
That sure explains the low number of infected patients worldwide. - bonoes, on 10/12/2007, -6/+0bury
- myxyplik, on 10/12/2007, -11/+5Better still... ABSTINENCE! (I dare the sluts to digg this down!)
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