Max Hodak, Neuralink co-founder, shared a Nature paper titled "Somatic mutations impose an entropic upper bound on human lifespan." He argues conventional biotech like gene and cell therapies can push more people toward the natural maximum of roughly 120 years but cannot meaningfully exceed it due to accumulating mutations. Investor Blake Byers replied that the biological wall may lie beyond 120, citing serial reprogramming experiments lasting over 50 generations. The discussion centers on whether AI-driven longevity efforts face hard physical limits from entropy rather than solvable engineering problems.