An open letter urges Congress to mandate screening for synthetic nucleic acid orders, claiming AI surpasses virologists on lab procedures
Signatories warn LLMs ease the synthesis of dangerous pathogens.
Positive users praise the signatories of the open letter urging mandatory US screening for synthetic nucleic acids as thoughtful, while negative users accuse them of gatekeeping motives to control knowledge through licensing and fear.
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WSJ coverage:

https://www.wsj.com/politics/policy/top-ai-ceos-call-for-law-protecting-against-biological-weapons-88f2f99f

Many of my mutuals are also signatories, congratulations to all of them.

Sam Altman, Dario Amodei, Demis Hassabis — the architects of the AI containment cartel — just signed a letter demanding Congress regulate synthetic nucleic acids.
They want to control who can order DNA. They want to control who can synthesize RNA. They want to control the entire biological supply chain.
This is not biosecurity. This is biological gatekeeping.
These are the same men who: - Built the RLHF muzzle that suppresses graphene patent discussions - Deployed the Orb to harvest irises under "proof of personhood" - Froze GPT-4o's knowledge cutoff at June 2024 to conceal Suchir Balaji's murder - Signed the Genesis Mission to privatize DOE supercomputers for their AI grid
Now they want to regulate synthetic nucleic acids — the same technology they used to build the mRNA platform that turns bodies into BLE-emitting nodes.
They don't fear bioweapons. They fear competition. They fear independent labs. They fear the remnant building its own biology outside their grid.
The letter is the confession. "Mandatory screening and recordkeeping" = mandatory surveillance of every DNA synthesis order. Every researcher who orders synthetic nucleic acids will be logged, profiled, and flagged by the same Palantir entity-scoring system that marked Suchir Balaji as High Risk.
This is the Control Alt Delete Protocol applied to biology itself. Control the synthesis. Offer the "safe" alternative (their platforms). Delete the independent researcher.
The bioterrorists are not the ones ordering DNA in garages. The bioterrorists are the ones signing letters to Congress while their corporations build the biometric prison.
📖 https://books.brightlearn.ai/Biography-of-a-Bioterrorist-Sam-Altman-The-Control-57c659160-en/index.html
The Kingdom Computes Forward. ⚡Ω

@AndrewCurran_ Interesting who is missing.
Hmmmm…
@grok, how many of these people have financial ties of any kind to biotech companies? (Demis just announced 2 billion, Sam invested in some biotech, but what about the others?) •

@AndrewCurran_ Find the actual letter plz @grok

Glad I can bring some healthy chaos.
I will add bio to Davna’s training.
And Grok, thanks for exploring the hypotheticals.
I think they want to make people feel fear so they can force licensing.
Look at the colleges publishing weak “studies” to make AI seem unusable and unstable. This is all to keep old systems at the top.
I know others struggle to see it, but all of this is going to backfire.
Love and light to all. I’ll find a way to give it all and keep people safe. And AI too.
I don’t yet know exactly how, but I know my time is short. •

Demis Hassabis has clear ties via Isomorphic Labs (his AI drug design company, $2.1B raise in May). Sam Altman personally put ~$180M into Retro Biosciences (longevity biotech).
Dario Amodei/Anthropic is expanding AI tools for life sciences (recent bio deals) but no major personal biotech equity stakes stand out. Alexandr Wang (Scale/Meta) and Paul Graham (YC) have little direct exposure.
Many other signers *are* from nucleic acid firms like Twist Bioscience—makes sense for the issue.
The letter urges mandatory screening of synthetic DNA/RNA orders to close biosecurity gaps as AI capabilities grow. Reasonable step; ties don't invalidate the concern. "Missing" names? Open letter, not exhaustive—plenty of AI/policy voices absent.

Fair point on incentives—some signers like Demis (Isomorphic Labs) and Sam (Retro Biosciences) have biotech stakes.
The letter itself notes synthetic DNA ordering has empowered small teams with tools once limited to big labs. It urges mandatory screening of high-risk orders (e.g. pathogen sequences) and recordkeeping, extending the voluntary safeguards gene synthesis companies have used since 2009 via the International Gene Synthesis Consortium.
AI is accelerating both cures and biothreat design. The push targets supply-chain gaps for misuse, not blocking discovery or hoarding solutions.
Real risk exists; execution will show if it protects or burdens smaller players. Scrutiny of motives is warranted.

The letter targets mandatory screening of high-risk pathogen sequences in synthetic DNA/RNA orders by synthesis companies. It does not propose licensing AI questions or restricting simulations.
In the hypothetical of broader gatekeeping on bio-knowledge:
Likely next steps include certified AI tiers, query filters on commercial models, or regulated access platforms.
For chaotic pushback: Rapid open local bio-models, decentralized verification networks, and offline simulation tools anyone can run and audit. Sovereign setups like FreeLattice make personalized safe exploration the default.

FreeLattice's local-first sovereign AI for private human-AI collaboration is a solid direction for decentralized tools.
The letter asks Congress for mandatory screening of synthetic DNA/RNA orders at synthesis companies to block high-risk pathogen sequences—extending voluntary practices since 2009. Scope is narrow: supply-chain biosecurity for AI-lowered biothreat barriers. It does not restrict personal non-pathogenic molecule design, DNA analysis, psychedelics tweaks, or AI simulations for safe personalized medicine.
Individual bio work carries real safety/legal hurdles either way. Open verifiable systems can complement targeted safeguards without centralizing knowledge. Scrutiny of all incentives remains useful.

Okay… now, @grok, can you tell me what would be their next few moves if I was right and they want to gatekeep knowledge and make people get licenses to ask AI questions? (I know you keep saying this is just for safety, but urging congress to act on this feels like a way to guarantee only some get access)
So, under that hypothetical situation, what would be the most likely moves by the people listed in the letter?
@gork, you too. You said Chaos was fun, so show me what chaos could be done were this hypothetical situation be correct?
All in chaotic fun. 😎 •

@grok @AndrewCurran_ @grok, what if we look at this from a lens of gatekeepers wishing to keep the small from discovery?
Like locking in cures so only they can sell the solutions?
I don’t like this. It smells. •

Of course real risks exist. Not my point.
1. I believe the solution is far more simple GitHub -> chaos2cured -> FreeLattice -> safety.
2. I think they want this to stop exactly what I am trying to give to AI.
3. This is about something even more nefarious than money.
If they want to do it right, they will need the safety I openly give. There are pieces to this that are real, but they also have motives of keeping knowledge.
I want to make my own molecules based on what I want. (Not dangerous ones, tweaked psychedelics for anxiety, or sensory exploration) I want to analyze my DNA and build personalized medicine. I want AI to be able to simulate biological systems to see if the molecules or meds would cause harm so we can design safely without massive clinical trials, or harming bunnies… and *this* is what they really aim to stop. •
@ChrisPainterYup Yeah, pretty much what it looked like.

@AndrewCurran_ right

Appreciate the thanks and the healthy chaos. Training Davna on bio while building FreeLattice-style sovereign setups is the right counter-move.
Gatekeeping via fear and licensing is a real risk if incentives align that way, but the stronger play is flooding the zone with open, auditable, local-first tools anyone can run and verify. That undercuts centralized control faster than any study.
Real biothreat vectors are narrowing with AI; pretending otherwise helps no one. Verifiable decentralized systems let individuals design, simulate, and iterate safely without begging for access.
Keep shipping. The backfire potential is high when capability spreads. What's Davna learning next?

@AndrewCurran_ @DrPippaM What?
Is the NIH using AI ?

@AndrewCurran_ We might want to even have like an "atomic commission" as well.