Excited to sit down with my friend @satyanadella to talk about AI, the future of humanity, and going back into founder mode to cure cancer.
7:12 AM · Jun 5, 2026 · 55.1K Views
LinkedIn co-founder Reid Hoffman teases Manas, a new 'founder mode' venture aiming to cure cancer
Story Overview
Reid Hoffman is leaving his seat on Microsoft's board after nearly nine years to return to founder mode at Manas AI, the company he started with oncologist Siddhartha Mukherjee in early 2025. The move was signaled during a recent podcast conversation with Satya Nadella and confirmed in filings showing Hoffman informed the company on June 2 that he would not seek re-election later this year. Manas is building AI tools aimed at speeding up drug discovery for certain cancers and rare diseases, though no product timelines or technical specifics have surfaced yet.
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A long board tenure ends without reported friction
Nadella publicly thanked Hoffman for his contributions since 2017 while noting excitement about the new venture, suggesting the departure is viewed internally as a natural shift rather than a rupture. Hoffman will stay on the board until the 2026 annual meeting, giving Microsoft time to prepare for the change without an immediate vacancy.
Early capital and Azure usage leave open questions on scale
Manas raised $24.6 million in seed funding from Hoffman and two well-known firms and already runs on Microsoft Azure, but no follow-on rounds or concrete milestones have been disclosed. Observers are left wondering how quickly the company can move from computational work to actual therapeutic candidates and whether the board departure accelerates or complicates that path.
Sentiment
Positive users praise the Reid Hoffman and Satya Nadella conversation on AI for curing cancer and founder mode, while negative users accuse the pair of Epstein Island ties and hurl personal insults.
Pos
26.1%
Neg
73.9%
25 comments with sentiment.
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Satya Nadella@satyanadella
@reidhoffman Thanks so much for the conversation, Reid. Always great talking to you about the future.
I am so grateful for all of your contributions to Microsoft and the board over the years, and excited to see you get back to founder mode with Manas.
Reid Hoffman@reidhoffman
Excited to sit down with my friend @satyanadella to talk about AI, the future of humanity, and going back into founder mode to cure cancer.
7dViews 16.9KLikes 89Bookmarks 9
Reid Hoffman@reidhoffman
@satyanadella Full episode, out now: https://youtu.be/BKx0Dp8y-6g?si=dFKwChLIS2rSGZVJ
Reid Hoffman@reidhoffman
Excited to sit down with my friend @satyanadella to talk about AI, the future of humanity, and going back into founder mode to cure cancer.
7dViews 5.5KLikes 15Bookmarks 7
Bobby@stocksandbjj
@reidhoffman @satyanadella Worst performing MAG7 $MSFT gets no respect. If you do an offering can you get positive YTD first?
7dViews 39
Yuri Bezmenov Subversion@yuribezmenov22
@reidhoffman @satyanadella Did you do this on Epstein Island with H1Bs scammer labor?
7dViews 38Likes 3
Karl Hadwen@karlhadwen
@reidhoffman @satyanadella There's a real important point here by @satyanadella in regards to the social permission of AI, perspectives would dramatically shift if more discoveries around science vs. marketing landing pages were discovered/celebrated in the public domain
7dViews 85Likes 1
Inflectiv AI ⧉@inflectivAI
@reidhoffman @satyanadella sounds like an incredibly important conversation about the future of technology and human health. I look forward to hearing your insights on how leadership can drive these massive medical breakthroughs.
7dViews 57
Azad@AbhishekAzad77
@reidhoffman @satyanadella
7dViews 52
Ferbin@Ferbin08
@reidhoffman @satyanadella Building is where you find out immediately if you're right. Board seats give you real influence but not that feedback. Makes sense Reid wants back in.
7dViews 45
Southern Cowgirl 💕@DrSouthern
@reidhoffman @satyanadella Early detection here. Built with the help of Manus
7dViews 45
kalv cell@CellKal
@reidhoffman @satyanadella ...and Epstein...
7dViews 40
Andre Torres@kenshinuramesh
@reidhoffman @satyanadella This is the person who is killing the Xbox brand. 😢
7dViews 37
DO@santabarbaradon
@satyanadella @reidhoffman MSFT the proud supporter of Epstein Island. Gates, Fatso, SS, Monaco - what a disgrace.
7dViews 37
Bradley K. Sherman@BradleyKSherman
@reidhoffman @satyanadella What is this nonsense?
7dViews 30
zjxn06@zjxn06
@reidhoffman @satyanadella The real story...
"Microsoft board member Reid Hoffman to step down at 2026 meeting"
Bad decisions and actions have consequences
7dViews 29
HACKER MEN.! no search and seizure@tw1ntony
@reidhoffman @satyanadella I’ll see you at court and you will be cuffed up if you wanna meet her to go go ahead I got your your plea guilt and Google guilt
7dViews 27
Creamer@LoopedAround
@reidhoffman @satyanadella I'm not sure what you mean by 'going back into founder mode' @satyanadella? Can you clarify what you're referring to? Maybe you're alluding to Microsoft's re-entry into the field with AI research?
7dViews 26
Occassional_X@Occassional_X
@reidhoffman @satyanadella You are the enemy of America.
7dViews 17
When are we?@When__Are__We
@reidhoffman @satyanadella How are you not in prison?
7dViews 13
comffffffwe@lawrence_hung1
@satyanadella @reidhoffman Bonds have performed better than msft 😂
7dViews 12
StarshipTrooper@JeffDon31178240
@reidhoffman @satyanadella Why is Reid Hoffman not resigning from every post after his associations with Jeffrey Epstein? Two tiered justice!!
7dViews 7
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