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NewLimit says its AI systems doubled drug discovery rates as it advances its first medicine toward clinical trials

The company also launched a program targeting endothelial cells.

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NewLimit@newlimit

Each year, we share a public update on our progress @newlimit from our lab in South San Francisco.

This year, we announced:

1. 2X increase in discovery rates with AI systems 2. New program focused on endothelial cells 3. 0 -> 1 medicines headed to the clinic

Full event video below

8:52 AM · Jun 9, 2026 · 22.2K Views
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Users are excited about NewLimit reporting 2X AI discovery gains and advancing its first medicine to clinic because it signals major progress in AI-driven drug development.

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Jacob Kimmel@jacobkimmel

every year @newlimit, we host friends at the lab & share our progress

for 2026, we announced:

- 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol

some highlights --

1dViews 171.7KLikes 183Bookmarks 55
BOOKMARKS130LIKES369RETWEETS44REPLIES25
Jacob Kimmel@jacobkimmel

in our 2026 @newlimit progress update, we announced our first candidate medicine.

it has the one of the most striking effects i’ve ever seen.

a single treatment accelerates recovery from alcohol in old animals. it’s so dramatic you can see it with your bare eyes!

1dViews 109.3KLikes 369Bookmarks 130
Martin Shkreli@MartinShkreli

why no paper, patent or structure

Jacob Kimmel@jacobkimmel

every year @newlimit, we host friends at the lab & share our progress

for 2026, we announced:

- 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol

some highlights --

15hViews 66.4KLikes 275Bookmarks 62
Martin Shkreli@MartinShkreli

this is so weird. at 2:25, he says there's no demo, there's just a tube with the drug. well, actually, you're supposed to show your MOA+structure, maybe cocrystal, i mean, anything about how it was discovered?

Jacob Kimmel@jacobkimmel

every year @newlimit, we host friends at the lab & share our progress

for 2026, we announced:

- 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol

some highlights --

15hViews 34.7KLikes 108Bookmarks 41
Martin Shkreli@MartinShkreli

uhhh 😂😂😂

Jacob Kimmel@jacobkimmel

in our 2026 @newlimit progress update, we announced our first candidate medicine.

it has the one of the most striking effects i’ve ever seen.

a single treatment accelerates recovery from alcohol in old animals. it’s so dramatic you can see it with your bare eyes!

23hViews 58.1KLikes 127Bookmarks 38
Martin Shkreli@MartinShkreli

well, there is a clue which is LNP and seemingly transcription factor soup? particularly since targeting a liver disease is the CRISPR/mRNA/RNAi/antisense cheat code--which paradoxically makes liver diseases much less exciting given everyone has gone after them. no meds for ALD though, so not a bad choice there

Jacob Kimmel@jacobkimmel

every year @newlimit, we host friends at the lab & share our progress

for 2026, we announced:

- 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol

some highlights --

15hViews 30.6KLikes 80Bookmarks 24