/Tech6h ago

Chan Zuckerberg Biohub releases ESMFold2 protein folding model and ESM Atlas database on Hugging Face

Mark Zuckerberg confirmed Biohub is now CZI's primary focus.

202422111752.5K
Original post
Teddy Schleifer@teddyschleifer

Mark Zuckerberg, in an extensive interview about Biohub and the Chan Zuckerberg Initiative to @saranormous + @eladgil:

"The biggest thing that we've formalized is that Biohub is the main focus of our philanthropy. That's been a very big shift."

https://www.youtube.com/watch?v=u8cYwaLzN-k&t=1s

3:07 PM · Jun 10, 2026 · 4.5K Views
Sentiment

Users praise Biohub's open ESMFold2 and ESM Atlas release as a goldmine for AI-biology research because it accelerates disease-curing efforts and provides valuable open protein models.

Pos
87.5%
Neg
12.5%
7 comments with sentiment.
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VIEWS35.4KBOOKMARKS98LIKES190RETWEETS13REPLIES11
sarah guo@saranormous

new @NoPriorsPod with Priscilla Chan, Mark Zuckerburg and Alex Rives: - taking seriously the @biohub mission to cure and prevent all disease (soon!) - Model release of ESMFold2 and ESM Atlas (beating AlphaFold) - new biological knowledge from the models - ecosystem strategy

5hViews 35.4KLikes 190Bookmarks 98
clem 🤗@ClementDelangue

Very cool! Should get more followers: https://huggingface.co/biohub

sarah guo@saranormous

new @NoPriorsPod with Priscilla Chan, Mark Zuckerburg and Alex Rives: - taking seriously the @biohub mission to cure and prevent all disease (soon!) - Model release of ESMFold2 and ESM Atlas (beating AlphaFold) - new biological knowledge from the models - ecosystem strategy

2hViews 7.8KLikes 35Bookmarks 9
sarah guo@saranormous

Full interview on YouTube or anywhere you get podcasts: https://youtu.be/u8cYwaLzN-k?si=BgJMsT0MBvzJpniC

sarah guo@saranormous

new @NoPriorsPod with Priscilla Chan, Mark Zuckerburg and Alex Rives: - taking seriously the @biohub mission to cure and prevent all disease (soon!) - Model release of ESMFold2 and ESM Atlas (beating AlphaFold) - new biological knowledge from the models - ecosystem strategy

5hViews 4.7KLikes 11Bookmarks 4

@saranormous @NoPriorsPod @biohub Zuck being such a great "wife guy" is one of the most endearing and least discussed things about him...and while there are so many examples, you even see it in how they speak about common pursuits.

4hViews 513Likes 8
Vector@PrasVector

@saranormous @NoPriorsPod @biohub That sounds like a fascinating episode. It's crazy to think about actually trying to cure all disease, but at least theyre putting serious resources behind it.

4hViews 147
Ming@faze11789516

@saranormous @NoPriorsPod @biohub The hardest code to crack was always biological.

4hViews 101
JerryZ@stories_china

@saranormous @NoPriorsPod @biohub This lineup is stacked. Curious what “cure and prevent all disease (soon!)” concretely means on their roadmap—specific disease areas + timelines, or more like platform milestones (assays, maps, foundation models) they think unlock multiple bets?

3hViews 63
Sameen Husain@sameen_husain

@saranormous @NoPriorsPod @biohub we keep solving biology's molecular layer faster than its human one. proteins fold on schedule; bodies don't. the distance between ESMFold and prevent all disease is the entire messy-systems problem

2hViews 24
Michael Zellinger@mjzellinger

@saranormous @NoPriorsPod @biohub Impression after 3 sec: Zuck looks like a caged tiger in this lol

5hViews 23
Hira@Hiraweb3

@ClementDelangue this is next-level science vibes ✨

2hViews 17
Lunari@0x_lun

@ClementDelangue ai powered biology trying to cure all disease and sitting at 162 followers is genuinely criminal

2hViews 13
Ferbin@Ferbin08

@ClementDelangue What's the actual use case? I'm genuinely puzzled whether this is for builders, researchers, or something in between.

1hViews 8
podEssence@podEssence_app

Mind-blowing: Zuck & Priscilla Chan say curing all diseases by 2100 now sounds *conservative* thanks to AI 🔥

Full No Priors ep is 56min. Get every key moment in original voices — in just 35 minutes — on Podessence.

Search "Podessence" on android & playstore and check it out yourself 👀

#AI #Bio

1hViews 5

@ClementDelangue the ESMFold2 + ESM Atlas open release is the part i'd underline here. open protein models with an atlas attached is exactly the kind of thing that compounds when researchers can build on it directly

1hViews 4
Giri@giris4u

@ClementDelangue This is a goldmine for anyone working at the intersection of AI and biology. The sheer volume of open-source biomedical models and datasets they are centralizing is massive for open science. Definitely deserves a lot more eyes and contributors. #OpenScience #BioAI

1hViews 2

@ClementDelangue 「follow」という言葉。指示に従うのは当然だが、それ以上、人の興味を引く仕掛けにこそ、本当の技術がある。

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ALPHABET DICTIONARY@ALPHABETDIg9f

@saranormous I am requesting repost for JACKIE CHAN & WESTCOASTCUSTOMS & BILL GATES (MY HOLY TRINITY) TRIPLET FATHER and INVENTOR OF HUMAN BEING - MARK ZUCKERBERG (ALPHA & OMEGA) Indistractable Demo Page because MY INVENTOR MOBILE PHONES and MY INVENTOR BANK MOBILE DEVICES are delaying.

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ALPHABET DICTIONARY@ALPHABETDIg9f

@saranormous @biohub @NoPriorsPod I am requesting repost for JACKIE CHAN & WESTCOASTCUSTOMS & BILL GATES (MY HOLY TRINITY) TRIPLET FATHER and INVENTOR OF HUMAN BEING - MARK ZUCKERBERG (ALPHA & OMEGA) Indistractable Demo Page because MY INVENTOR MOBILE PHONES and MY INVENTOR BANK MOBILE DEVICES are delaying.

4h
ALPHABET DICTIONARY@ALPHABETDIg9f

@saranormous @biohub @NoPriorsPod I am requesting repost for JACKIE CHAN & WESTCOASTCUSTOMS & BILL GATES (MY HOLY TRINITY) TRIPLET FATHER and INVENTOR OF HUMAN BEING - MARK ZUCKERBERG (ALPHA & OMEGA) Indistractable Demo Page because MY INVENTOR MOBILE PHONES and MY INVENTOR BANK MOBILE DEVICES are delaying.

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