/Tech1d ago

Anthropic releases Claude Fable 5, which autonomously executed a drug design loop across 14 protein targets

The automation accelerated protein design by ten times.

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Original postSuper Dario#1958
vittorio@IterIntellectus

the next few years are going to be sci-fi

Claude@claudeai

Introducing Claude Fable 5: a Mythos-class model that we’ve made safe for general use.

Its capabilities exceed those of any model we’ve ever made generally available.

10:29 AM · Jun 9, 2026 · 38.2K Views
Sentiment

Positive users celebrate Claude Fable 5's autonomous drug design on protein targets as groundbreaking, while negative users criticize censorship blocking medical queries and doubt real healthcare benefits.

Pos
57.5%
Neg
42.5%
43 comments with sentiment.
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VIEWS2.7KBOOKMARKS2LIKES61REPLIES3

@BoWang87 How?? I got flagged even for this!

1dViews 2.7KLikes 61Bookmarks 2
RETWEETS1

@BoWang87 1. Not crazy really. Opus and even sonnet can run design loops. 2. Image showed mini binders and all in silico candidates no lab mention. 3. It’s unusable for bio/bio locked so can’t verify therefore not reliable.

Benchmarks look insane but it’s just not usable

1dViews 586Likes 4
Anthony@anthonystaj

@BoWang87 can you post proof this happened? everyone else in the community is getting blocked for sayin hi to Fable but you were able to do novel drug discovery?

1dViews 360Likes 8
Dr. Alex Tatem@DrAlexTatem

@BoWang87 TF are you talking about? It blocks any discussion of biology whatsoever 😂

22hViews 338Likes 3Bookmarks 1
Owen Lewis@is_OwenLewis

@IterIntellectus AGI when?

Next year "soft" AGI is my guess. Full, whatever exactly that looks like, by 2030 but probably sooner.

1dViews 182Likes 5
Adam Rossi@rossiadam

@IterIntellectus Last invention we ever need to make at some point

1dViews 302Likes 4Bookmarks 1
Oli@nolive

@IterIntellectus We better see drug and healthcare costs dropping like flies.

But somewhat, i don't trust the healthcare cartel in doing that.

1dViews 278Likes 4Bookmarks 1
Peter Ciaccia@PeterCiaccia

@BoWang87 how? I'm building biology software but am currently getting flagged for trying to implement multithreading and for basic webgl rendering...

1dViews 427Likes 6
BioLLM@BioLLM_

@BoWang87 Look but don’t touch right? Censorship.

1dViews 201Likes 2Bookmarks 1
anabology@anabology

@BoWang87 If only we could use it

1dViews 548Likes 8
Ash Jogalekar@curiouswavefn

Are you in a special access program? It seems to be rejecting basically every biology and drug discovery prompt I am throwing at it. Also, the capabilities you are describing are present in Codex as well. Last week I ran a 47-hour-long pipeline doing a full structure and ligand-based pipeline for six drug discovery targets; full tooling, error-handling and reasoning. What do you think is distinctive about Fable, specifically?

23hViews 506Likes 4
Rogu@RomanGuy20

@DeryaTR_ @BoWang87 Every time I give a try to Anthropic, I remember why I love OpenAI the most out of frontier labs.

1dViews 143Likes 8
Melinda B. Chu@MelindaBChu1

@BoWang87 Did you synthesize them or just computational benchmarks?

I guess you’re one of the lucky elites. Everyone else is poor plebeians.

1dViews 282Likes 7
Connor@riegalski

@PeterCiaccia @BoWang87 I was able to get it to work on an LNP pipeline without issue. I turned off memory to prevent any old project threads from flagging

1dViews 57Bookmarks 1
Curt Tigges@CurtTigges

@IterIntellectus "aspects"

you have to consider Amdahl's Law. they definitely did not accelerate the whole process by 10x, but probably small sub-parts.

21hViews 42Bookmarks 1
Jack Hansen@hansen_jack_

@BoWang87 Too bad it’s not smart enough to tell the difference between basic biology questions and engineering a bioweapon

1dViews 164Likes 2
UBERSOY@UBERSOY1

@IterIntellectus AGIAGIAGIAGI

1dViews 369Likes 5
jodavaho@jodavaho

@is_OwenLewis @IterIntellectus At this rate, AGI is less important than just getting AI into specialized use cases as fast as possible.

Most of these gains are from claude automating a human-engineered workflow and speeding it up! More of that please.

1dViews 15Likes 3

@BoWang87 No one in bio or health can use it. Every single health related question is flagged as a security risk

1dViews 218Likes 4
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