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AI Analysis of CT Scans Flags Up to 30-Fold Cardiac Death Risk

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The study cited in the article that I considered a wake-up call found a 13-fold risk of cardiac mortality with 1 inflamed artery, which rose to nearly 30-fold when all 3 arteries were inflamed, as determined by AI of non-invasive CT angio imaging https://www.thelancet.com/article/S0140-6736(24)00596-8/fulltext

Eric Topol@EricTopol

The next frontier for prevention of heart and vascular disease isn't targeting lipids. It's about blocking inflammation. These are some of the ongoing clinical trials @NatureMedicine https://www.nature.com/articles/d41591-026-00030-6

7:06 AM · Jun 6, 2026 · 1.7K Views

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Users appreciate the AI CT imaging claim that inflamed arteries raise cardiac death risk up to 30-fold because it draws a great parallel to existing medical knowledge.

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Eric Topol@EricTopol

And that markedly elevated risk of inflammation was similar with no significant narrowing/blockage known as obstructive coronary artery disease (CAD)

Eric Topol@EricTopol

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Eric Topol@EricTopol

If you find this big shift interesting, it's reviewed in a Ground Truths post, which are all open-access, free https://erictopol.substack.com/p/the-big-shift-in-cardiology-to-atheroma

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Esteban F-Hinojosa@EFdezHinojosa

I recall that with the evolution of our understanding of sepsis and ARDS, we moved from focusing solely on the visible lesion to recognizing that the host’s inflammatory response is as consequential as the initial insult. A similar conceptual shift appears to be emerging in coronary artery disease

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Eric Topol@EricTopol

@EFdezHinojosa Yes, great parallel. Thanks.

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ResearchPulse@ResearchPulse1

@EricTopol @A_May_MD

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