Scientists discover the enzyme that lets cancer rapidly rewire its DNA

Researchers at the University of California San Diego have identified the enzyme N4BP2 responsible for chromothripsis, a process where chromosomes break into fragments and reassemble incorrectly, seen in about one in four cancers. This chaotic reshuffling allows cancer cells to evolve rapidly and develop resistance to treatment. Blocking the enzyme significantly reduced genomic destruction in cancer cells, offering a potential new strategy for treating aggressive cancers.