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Experimental COVID-19 mRNA vaccine formulation remains stable after a year at room temperature

MIT News reports that researchers used AI to find stabilizing ingredients for the particles that deliver mRNA. After a year at room temperature, experimental vaccine doses produced immune responses in mice comparable to doses using particles similar to Moderna’s.

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TLDR

MIT News reports that researchers used an AI algorithm to select ingredients for the particles that protect and deliver mRNA. They vacuum-dried experimental COVID-19 vaccine doses, then stored them for a year at room temperature or two months at 98°F. In mice, the stored doses produced immune responses comparable to vaccines using particles similar to Moderna’s. The team also tested the formulation in vaccine-delivering microneedle patches.

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2 Sources

MIT News | Massachusetts Institute of TechnologyNew formulation helps RNA vaccines withstand high temperatures
NatureAccelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI
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    2 Sources

    MIT News | Massachusetts Institute of TechnologyNew formulation helps RNA vaccines withstand high temperatures
    NatureAccelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI
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