STAT News says Moderna's Stephen Hoge discussed the Merck partnership behind an mRNA cancer vaccine at the STAT Summit.
At the STAT Summit, Stephen Hoge of Moderna spoke about the company's partnership with Merck, which STAT News says produced an mRNA vaccine for cancer.
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STAT’s post from the summit says Stephen Hoge of Moderna discussed the company’s partnership with Merck on an mRNA cancer vaccine. The program’s lead candidate, intismeran autogene, is an investigational treatment tailored to an individual patient. It is not a preventive vaccine for healthy people.
Intismeran, also known as V940 or mRNA-4157, starts with a sample of a patient’s tumor. Researchers identify mutations unique to that cancer and build a synthetic mRNA sequence encoding as many as 34 neoantigens. The aim is to teach the immune system to recognize those markers and generate T-cell responses against cancer cells.
Merck and Moderna are developing the therapy together and testing it with Keytruda, Merck’s approved anti-PD-1 immunotherapy. The combination is being studied after surgery, when treatment is intended to lower the risk that cancer returns.
In an Aug. 19 joint announcement, the companies said the Phase 3 INTerpath-001 trial met its main goal of improving recurrence-free survival and a key secondary goal of improving distant metastasis-free survival compared with Keytruda alone. The study enrolled 1,137 people whose stage IIB to IV cutaneous melanoma had been completely removed.
Those are topline company results, not yet a full public data presentation. The announcement did not provide the detailed outcome numbers, and the trial is continuing to evaluate overall survival. Merck and Moderna said they plan to present the data at a medical meeting and discuss potential filings with regulators. Until those steps are complete, intismeran remains investigational.
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@statnewsStephen Hoge of Moderna talks about the partnership with Merck that produced an mRNA vaccine for cancer. #STATSummit@statnewsStephen Hoge of Moderna talks about the partnership with Merck that produced an mRNA vaccine for cancer. #STATSummit@statnewsStephen Hoge of Moderna talks about the partnership with Merck that produced an mRNA vaccine for cancer. #STATSummit@statnewsStephen Hoge of Moderna talks about the partnership with Merck that produced an mRNA vaccine for cancer. #STATSummit
