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    Bacterial defense system reportedly uses a protein as a DNA blueprint

    A post attributes the finding to Stanford researchers, saying the DRT3 system uses amino acids in an enzyme to determine which DNA letters to add—without a DNA template or RNA guide.

    SupermanSU
    1 Source, 28d ago, first seen 28d ago

    TLDR

    A post says Stanford researchers discovered that DRT3, a bacterial defense system, builds DNA during a viral attack without copying an existing genetic template. The account describes the protein itself as the blueprint, with specific amino acids determining which DNA letters are added. The author suggests the mechanism could have biotechnology applications if it can be engineered.

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    1 Source, first seen 28d ago

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    Combined views

    1.7K

    1 Source, first seen 28d ago

    36 likes5 comments15 saves10 reposts

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    1 Source

    Superman@thesupermannxStanford broke a 70-year-old rule of biology. They discovered proteins can directly guide DNA synthesis. i am speechless.. this is a fundamentally new way for life to create DNA.. For decades, every textbook in the world has taught the exact same fundamental law. DNA makes RNA. RNA makes protein. Information flows in one direction. Once genetic code becomes a physical protein, it can never go back. That was the absolute law of life, established by Francis Crick in 1958. Until today. Researchers at Stanford just discovered a bacterial defense system that completely rewrites how biology works. It's called DRT3. When a virus attacks, this system builds a new strand of DNA to defend the cell. But it doesn't copy an existing genetic template to do it. The protein itself acts as the blueprint. Specific amino acids within the enzyme physically dictate exactly which DNA letters to place next. It builds a customized strand of DNA completely out of thin air. No parent DNA. No RNA guide. The hardware is writing its own software. It proves that the physical structure of a protein can directly synthesize sequence-specific genetic information. Right now, it is just a bacterial defense mechanism. But if we can engineer this, the implications for biotechnology are staggering.28d
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    Stanford

    1 Source

    Superman@thesupermannxStanford broke a 70-year-old rule of biology. They discovered proteins can directly guide DNA synthesis. i am speechless.. this is a fundamentally new way for life to create DNA.. For decades, every textbook in the world has taught the exact same fundamental law. DNA makes RNA. RNA makes protein. Information flows in one direction. Once genetic code becomes a physical protein, it can never go back. That was the absolute law of life, established by Francis Crick in 1958. Until today. Researchers at Stanford just discovered a bacterial defense system that completely rewrites how biology works. It's called DRT3. When a virus attacks, this system builds a new strand of DNA to defend the cell. But it doesn't copy an existing genetic template to do it. The protein itself acts as the blueprint. Specific amino acids within the enzyme physically dictate exactly which DNA letters to place next. It builds a customized strand of DNA completely out of thin air. No parent DNA. No RNA guide. The hardware is writing its own software. It proves that the physical structure of a protein can directly synthesize sequence-specific genetic information. Right now, it is just a bacterial defense mechanism. But if we can engineer this, the implications for biotechnology are staggering.28d
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