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Reprogrammed cells from an 80-year-old reportedly show under-20 molecular age

University of Bonn researchers report converting red-blood-cell precursors directly into neural stem cells, bypassing a pluripotent stage.

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Fluorescence microscope image from the University of Bonn: a dense field of induced neural stem cells grown from the blood cells of a 101-year-old donor, with green cell skeletons and magenta-blue nuclei on a black background.

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In a lab experiment, cells from an 80-year-old individual acquired molecular age signatures corresponding to someone younger than 20, according to a University of Bonn account reproduced by Mirage News. The account says researchers converted red-blood-cell precursors directly into neural stem cells and tracked the gradual clock change for over 100 days. The reading reflects DNA modifications, not a younger person or an established treatment.

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A University of Bonn account reproduced by Mirage News says researchers at the University Hospital of Bonn and the University of Bonn directly converted red-blood-cell precursors into neural stem cells in a laboratory experiment. It reports that cells from an 80-year-old individual subsequently showed molecular age signatures corresponding to someone younger than 20.

According to the Bonn account, the researchers used epigenetic clocks, which estimate molecular age from chemical modifications to DNA. Those modifications do not change the DNA sequence itself. The account describes an approximately 60-year reduction in the clock reading after 50 days and says the change could be tracked for more than 100 days. These were measurements of cells in a lab, not a reversal of the person’s age. Dr. Ameneh Arabi made the same distinction: a younger clock reading does not mean a younger person.

Professor Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University Hospital of Bonn, said the team converted the cells without first passing through a pluripotent stem-cell stage. He said the gradual change offers a model for investigating which factors and substances speed up or slow down the reset. The Bonn account describes possible relevance to Alzheimer’s research, but says the work does not establish a treatment that reverses aging in people.

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Reprogrammed cells from an 80-year-old reportedly show under-20 molecular age

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