Three adults had sharply fewer seizures after experimental gene therapy and a drug

Three adults with drug-resistant epilepsy experienced sharply fewer monthly seizures after targeted brain gene therapy followed by low-dose clozapine. No serious side effects were reported. But the small, uncontrolled trial was designed to assess safety, not establish effectiveness. The observations do not establish long-term safety or show whether the improvement came from the combination, either component alone or another explanation.