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Reported colorectal cancer-cell reprogramming and Microsoft's early-stage Quine AI

A post says a KAIST team identified three genes whose combined suppression shifted colorectal cancer cells toward normal-like intestinal cells in lab tests. Separately, Microsoft describes Quine as an early-stage AI project for studying biology.

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2 Sources, 1d ago, first seen 1d ago

TLDR

A September 30 post says KAIST researchers used a computational model of healthy colon-cell gene networks to identify MYB, HDAC2 and FOXA2. Suppressing all three reportedly shifted colorectal cancer cells toward normal-like intestinal cells in three cell lines and showed anti-cancer effects in animals. Separately, Microsoft says its early-stage Quine project aims to help researchers explore biological questions and prioritize hypotheses before lab work.

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2 Sources, first seen 1d ago

133 likes2 comments27 saves44 reposts

Combined views

3K

2 Sources, first seen 1d ago

133 likes2 comments27 saves44 reposts

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2 Sources

@fascinatingonXSouth Korean scientists just talked cancer cells into becoming normal again. Forget chemo and radiation. This time, nobody tried to kill anything. A KAIST team built a computational "digital twin" of the gene network that guides healthy colon cells, then hunted for the switches controlling a cell's identity. They landed on MYB, HDAC2 and FOXA2. Suppress all three together and colorectal cancer cells shifted toward normal-like intestinal cells, while pathways driving runaway growth dropped. And it didn't stay on a screen. It held up in three colorectal cancer cell lines and showed anti-cancer effects in animals. Human trials come next. Cancer treatment that rewrites the enemy instead of destroying it. Source: KAIST; Advanced Science
@TheDevoooorThis is fresh. Microsoft just released the first ever Biological AI model that is meant to solve cancer Apparently they have been working on this for a total of 2 decades https://microsoft.com/en-us/research/blog/introducing-quine-an-ai-research-system-designed-for-the-complexity-of-biology/
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    2 Sources

    @fascinatingonXSouth Korean scientists just talked cancer cells into becoming normal again. Forget chemo and radiation. This time, nobody tried to kill anything. A KAIST team built a computational "digital twin" of the gene network that guides healthy colon cells, then hunted for the switches controlling a cell's identity. They landed on MYB, HDAC2 and FOXA2. Suppress all three together and colorectal cancer cells shifted toward normal-like intestinal cells, while pathways driving runaway growth dropped. And it didn't stay on a screen. It held up in three colorectal cancer cell lines and showed anti-cancer effects in animals. Human trials come next. Cancer treatment that rewrites the enemy instead of destroying it. Source: KAIST; Advanced Science
    @TheDevoooorThis is fresh. Microsoft just released the first ever Biological AI model that is meant to solve cancer Apparently they have been working on this for a total of 2 decades https://microsoft.com/en-us/research/blog/introducing-quine-an-ai-research-system-designed-for-the-complexity-of-biology/
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