Nuclear envelope rupture identified as key driver of LMNA-related cardiomyopathy

LMNA-related dilated cardiomyopathy is among the most severe forms of the condition, with limited treatment options. Cornell's Lammerding Lab says nuclear envelope rupture is a key driver. In a mouse model, the researchers disrupted the link between the nucleus and cytoskeleton to study rupture's role; the paper reports that reducing rupture rescued gene expression and survival. The findings suggest a possible treatment path focused on nuclear stability despite the genetic defect.