Experimental CRISPR treatment reportedly cut LDL cholesterol 52.5% after a year in four highest-dose patients
A post citing CNN says the Cleveland Clinic trial enrolled 15 people with lipid disorders resistant to medication. The treatment, CTX310, edits the ANGPTL3 gene in liver cells.
TLDR
ScienceDaily reports that a single dose of an experimental CRISPR treatment lowered LDL cholesterol and triglycerides by about half in patients with difficult-to-treat lipid disorders. A post citing CNN says four of the trial’s 15 participants received the highest dose; after one year, their LDL was down 52.5% and triglycerides were down 47.8%. The post says researchers reported no serious treatment-related adverse events during the first 12 months and plan 15 years of safety follow-up.
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