DNA repair’s role in maintaining extrachromosomal DNA and cancer fitness
Nature reports that DNA outside chromosomes, known as ecDNA, relies on a repair pathway called MMEJ for stability. The research focuses on breaks at fragile TA-rich sites.
TLDR
Nature reports that microhomology-mediated end joining (MMEJ), a DNA repair process, repairs breaks at fragile TA-rich sites and helps maintain extrachromosomal DNA (ecDNA) and cancer fitness. It also reports that FANCM suppresses break formation.
DNA repair’s role in maintaining extrachromosomal DNA and cancer fitness
Nature reports that DNA outside chromosomes, known as ecDNA, relies on a repair pathway called MMEJ for stability. The research focuses on breaks at fragile TA-rich sites.
TLDR
Nature reports that microhomology-mediated end joining (MMEJ), a DNA repair process, repairs breaks at fragile TA-rich sites and helps maintain extrachromosomal DNA (ecDNA) and cancer fitness. It also reports that FANCM suppresses break formation.