DNA repair’s role in maintaining extrachromosomal DNA and cancer fitness
Nature reports that DNA outside chromosomes, known as ecDNA, relies on a repair pathway called MMEJ for stability. The research focuses on breaks at fragile TA-rich sites.
TLDR
Nature reports that microhomology-mediated end joining (MMEJ), a DNA repair process, repairs breaks at fragile TA-rich sites and helps maintain extrachromosomal DNA (ecDNA) and cancer fitness. It also reports that FANCM suppresses break formation.
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