ScienceHuman brain organoids reportedly grow and integrate in engineered ‘xenocortical’ mice
Sergiu Pașca says his team created mice in which about 98% of the cortex and hippocampus fail to form, leaving room for transplanted human cortical organoids—lab-grown brain tissue models.
TLDR
Sergiu Pașca says his team’s approach, reported in Nature, aims to study human brain development and model disease in living animals. He explains that rodent brains mature much faster than human cortical cells, constraining transplanted cells’ growth and integration. The team created mice in which about 98% of the cortex and hippocampus fail to form, providing space for human cortical organoids to grow and integrate extensively. They call these “xenocortical” mice, or XCX. Pașca described the work as nearly seven years in the making.
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Human brain organoids reportedly grow and integrate in engineered ‘xenocortical’ mice
Sergiu Pașca says his team created mice in which about 98% of the cortex and hippocampus fail to form, leaving room for transplanted human cortical organoids—lab-grown brain tissue models.