ScienceAlphaFold reportedly helped uncover an ‘off switch’ for a cellular transport protein
A post says Cornell researchers followed an AlphaFold lead with experiments showing that the poorly understood protein Avl9 acts as an “off switch” for Arf1, which is involved in transport within cells.
TLDR
According to a post, Cornell researchers used AlphaFold to search for previously unknown protein interactions, leading them to Avl9. Subsequent experiments showed that Avl9 acts as an “off switch” for Arf1, a protein involved in transport within cells. The account also describes evidence of a broader family of proteins performing similar functions. It connects the findings to cell movement and cancer, which involve these cellular transport systems.
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AlphaFold reportedly helped uncover an ‘off switch’ for a cellular transport protein
A post says Cornell researchers followed an AlphaFold lead with experiments showing that the poorly understood protein Avl9 acts as an “off switch” for Arf1, which is involved in transport within cells.
TLDR
According to a post, Cornell researchers used AlphaFold to search for previously unknown protein interactions, leading them to Avl9. Subsequent experiments showed that Avl9 acts as an “off switch” for Arf1, a protein involved in transport within cells. The account also describes evidence of a broader family of proteins performing similar functions. It connects the findings to cell movement and cancer, which involve these cellular transport systems.