MIT engineers reprogram immune cells inside the body to target cancer and autoimmune disease

MIT News reports that in mice, about 80% of targeted natural killer cells were reprogrammed. Three of five mice with melanoma went into complete remission; tumors were eradicated after five injections in a humanized T-cell lymphoma model, and liver damage healed after one injection in mice with autoimmune hepatitis. The approach could bypass the time and expense of manufacturing these cells outside the body.