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    Ethical objections to human brain cell transplants in mice

    A post says transplanted human cells partially restored lost function in genetically altered mice, but objects to the procedure and to low-oxygen tests meant to cause brain damage.

    Sterling Crispin 🕊️SC
    1 Source, 27d ago, first seen 27d ago

    TLDR

    A post linking to a Nature paper criticizes experiments it says researchers call “xenocortication.” According to the author, transplanted human brain cells colonized 90% of the cortex in genetically altered mice and partially restored lost function. The author also says some mice were exposed to low oxygen to cause brain damage. They argue the work crossed an ethical line and say Stanford’s animal-care and stem-cell research oversight committees approved it.

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    1 Source, first seen 27d ago

    61 likes7 comments19 saves4 reposts

    Combined views

    6.8K

    1 Source, first seen 27d ago

    61 likes7 comments19 saves4 reposts

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    1 Source

    Sterling Crispin 🕊️@sterlingcrispinThe latest in man made horrors beyond comprehension, scientists genetically engineered mice missing 50% of their brain then cut their skulls open and injected them with human brain cells that grew and colonized 90% of their cortex, forming a human-mouse hybrid. The scientists are calling it “xenocortication” because it’s not just the human brain organoid taking up space. It actually partially restored function that the genetically altered missing-brain mice lost, with the human brain cells forming neurons into the mouse brain cells and integrating into it. Then for some of the xenocortex mice they suffocated them in a low oxygen box to give them brain damage, just to see how crippled up they would become! I guess it’s a way of studying human brain development but I feel like this is way beyond the line of ethical research. I don’t see why doing something like this to another living creature, especially in the context where an animal research ethics board reviewed it. Stanford’s Institutional Animal Care and Use Committee and Stem Cell Research Oversight committee both signed off on this. https://www.nature.com/articles/s41586-026-11032-227d
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    1 Source

    Sterling Crispin 🕊️@sterlingcrispinThe latest in man made horrors beyond comprehension, scientists genetically engineered mice missing 50% of their brain then cut their skulls open and injected them with human brain cells that grew and colonized 90% of their cortex, forming a human-mouse hybrid. The scientists are calling it “xenocortication” because it’s not just the human brain organoid taking up space. It actually partially restored function that the genetically altered missing-brain mice lost, with the human brain cells forming neurons into the mouse brain cells and integrating into it. Then for some of the xenocortex mice they suffocated them in a low oxygen box to give them brain damage, just to see how crippled up they would become! I guess it’s a way of studying human brain development but I feel like this is way beyond the line of ethical research. I don’t see why doing something like this to another living creature, especially in the context where an animal research ethics board reviewed it. Stanford’s Institutional Animal Care and Use Committee and Stem Cell Research Oversight committee both signed off on this. https://www.nature.com/articles/s41586-026-11032-227d
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