ScienceCohesin’s role in slowing and reversing replication forks
Nature reports that cohesin reshapes contacts at DNA-copying sites called replication forks, helping them slow down and reverse under replication stress.
TLDR
Nature reports that cohesin-mediated loop extrusion limits coupling between sister replication forks and tethers nearby forks under replication stress. The research links these changes in fork contacts to fork reversal and slower fork progression.
Cohesin’s role in slowing and reversing replication forks
Nature reports that cohesin reshapes contacts at DNA-copying sites called replication forks, helping them slow down and reverse under replication stress.