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Cancer trial drug zavondemstat reportedly largely blocks DHODH rather than KDM4

Medical Xpress says the unexpected target mismatch may have implications for the drug’s ongoing clinical development.

Medical XpressMX
Phys.orgPH
2 Sources, 2h ago, first seen 2h ago

TLDR

Medical Xpress reports that zavondemstat, a drug in cancer trials, largely blocks DHODH rather than its expected target, KDM4. The outlet says the mismatch may have implications for its ongoing clinical development.

Combined views

1.4K

2 Sources, first seen 2h ago

6 likes2 saves3 reposts

Combined views

1.4K

2 Sources, first seen 2h ago

6 likes2 saves3 reposts

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2 Sources

Medical Xpress@medical_xpressCancer trial drug zavondemstat largely blocks a different target than expected: DHODH rather than KDM4, a mismatch that may have implications for its ongoing clinical development. @nchembio https://medicalxpress.com/news/2026-10-cancer-trial-drug-differently-scientists.html?utm_source=twitter.com&utm_medium=social&utm_campaign=v22h
Phys.org@physorg_comRT @medical_xpress: Cancer trial drug zavondemstat largely blocks a different target than expected: DHODH rather than KDM4, a mismatch that…2h
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    2 Sources

    Medical Xpress@medical_xpressCancer trial drug zavondemstat largely blocks a different target than expected: DHODH rather than KDM4, a mismatch that may have implications for its ongoing clinical development. @nchembio https://medicalxpress.com/news/2026-10-cancer-trial-drug-differently-scientists.html?utm_source=twitter.com&utm_medium=social&utm_campaign=v22h
    Phys.org@physorg_comRT @medical_xpress: Cancer trial drug zavondemstat largely blocks a different target than expected: DHODH rather than KDM4, a mismatch that…2h
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