Dysregulated NF-κB dynamics linked to premature B-cell differentiation in aging mice

Cell Press Blue reports that healthy B-cell development involves dynamic NF-κB regulation, which is disrupted in aged mice. The researchers say this disruption rushes differentiation, reducing the quantity and quality of B cells produced from each lymphoid progenitor. They note that bone marrow B-cell output drops sharply with age and that myeloid-biased stem cell differentiation is another cause.