TRAM's role in Toll-like-receptor-free myddosome signaling
Nature describes TRAM as a regulator of myddosome assembly that separates MyD88 from the TLR–TIRAP complex, enabling the myddosome to mature and sustain downstream signaling.
TLDR
A Nature research paper reports that TRAM promotes myddosome signaling without Toll-like receptors. It describes TRAM separating MyD88 from the TLR–TIRAP complex, allowing the myddosome to mature and sustain downstream signaling.
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