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Sirtuin-3 may help predict how tumor cells respond to mitocan drugs

Sputnik, citing the Russian Science Foundation, says high sirtuin-3 levels were linked to resistance in lung cancer, ovarian cancer and neuroblastoma cell lines.

SputnikSP
F. Niro GhadakiFN
2 Sources, 5h ago, first seen 5h ago

TLDR

Sputnik reports, citing the Russian Science Foundation, that Russian and Swedish scientists identified sirtuin-3 as a possible biomarker for response to mitochondria-targeting mitocan drugs. In cancer cell-line tests, reducing the protein made resistant cells sensitive to treatment, while increasing it made sensitive cells more resistant.

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2 Sources, first seen 5h ago

47 likes5 comments6 saves27 reposts

Combined views

2.6K

2 Sources, first seen 5h ago

47 likes5 comments6 saves27 reposts

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2 Sources

Sputnik@SputnikIntRussian scientists uncover protein that may guide personalized cancer treatment Scientists from Russia and Sweden identified sirtuin-3 as a potential biomarker for predicting whether tumor cells will respond to mitochondria-targeting mitocan drugs, the Russian Science Foundation (RSF) told Sputnik. 🔸High sirtuin-3 levels were linked to drug resistance, while cancer cells with low levels of the protein were more easily killed by the mitocan 🔸Researchers tested the effect in lung cancer, ovarian cancer, and neuroblastoma cell lines, comparing tumors with naturally high and low sirtuin-3 levels 🔸When scientists reduced sirtuin-3 in resistant cells, they became sensitive to treatment; increasing the protein in sensitive cells made them more resistant 🔸Sirtuin-3 appears to protect tumor cells from the oxidative stress caused by mitochondrial disruption, helping explain why the same drug works in some tumors but not others The finding should help doctors predict mitocan effectiveness before treatment and design more personalized cancer therapies.5h
F. Niro Ghadaki@FNGhadakiLast Week In #Science (Sep 26–Oct 2) Just 5 Infections caused 12% of #cancer cases IBM's #QuantumComputer #Creatine w/o exercise still boosts strength Feathered dinosaur Aspirin→lower #dementia risk (certain genetics) #Superconductor could aid #QuantumComputing via @ScienceAlert4h
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    2 Sources

    Sputnik@SputnikIntRussian scientists uncover protein that may guide personalized cancer treatment Scientists from Russia and Sweden identified sirtuin-3 as a potential biomarker for predicting whether tumor cells will respond to mitochondria-targeting mitocan drugs, the Russian Science Foundation (RSF) told Sputnik. 🔸High sirtuin-3 levels were linked to drug resistance, while cancer cells with low levels of the protein were more easily killed by the mitocan 🔸Researchers tested the effect in lung cancer, ovarian cancer, and neuroblastoma cell lines, comparing tumors with naturally high and low sirtuin-3 levels 🔸When scientists reduced sirtuin-3 in resistant cells, they became sensitive to treatment; increasing the protein in sensitive cells made them more resistant 🔸Sirtuin-3 appears to protect tumor cells from the oxidative stress caused by mitochondrial disruption, helping explain why the same drug works in some tumors but not others The finding should help doctors predict mitocan effectiveness before treatment and design more personalized cancer therapies.5h
    F. Niro Ghadaki@FNGhadakiLast Week In #Science (Sep 26–Oct 2) Just 5 Infections caused 12% of #cancer cases IBM's #QuantumComputer #Creatine w/o exercise still boosts strength Feathered dinosaur Aspirin→lower #dementia risk (certain genetics) #Superconductor could aid #QuantumComputing via @ScienceAlert4h
    Today's Rank

    #7

    Today's Rank

    #7