Targeting ZMYND8 unleashes IL-2 signaling to override T cell exhaustion
Nature reports that ZMYND8 suppresses IL-2R–STAT5 signaling by inhibiting p300-mediated activation of Il2ra, enforcing terminal exhaustion in CD8+ T cells.
TLDR
Nature reports that targeting ZMYND8 unleashes IL-2 signaling to override T cell exhaustion. The paper says ZMYND8 inhibits p300-mediated activation of Il2ra, suppressing IL-2R–STAT5 signaling and enforcing terminal exhaustion in CD8+ T cells.
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