Uncovering the Mystery Behind Cold Sensation and Menthol’s Cooling Effect | Discover Magazine

Researchers from Duke University have solved a decades-old mystery about how the body senses cold and why menthol feels cool, using advanced microscopy technology. Their discovery reveals how distinct temperatures trigger the TRPM8 receptor to alarm our nervous system and explains the cooling sensation caused by menthol. This breakthrough may lead to new treatments for pain, migraines, and dry eyes.