20h ago

Preprint Shows ESM-2 And ESM-3 Capture Mostly The Same Protein Biology

——0——
Original post
Anshul KundajeAK#1675@ANSHULKUNDAJEOP🧬Jacob L Steenwyk🧬L🧬Jacob L Steenwyk|@JLSTEENWYK

NEW preprint: Sparse autoencoders were trained on ESM-2 (650M, seq-only) and ESM-3 (1.4B, multimodal) to ask a simple question -- when two protein language models look at the same protein, do they "see" the same biology? Answer: Yes, mostly

12:13 PM · May 26, 2026 View on X

Sentiment

Pos100%
Neg0%

Users praised the preprint showing ESM-2 and ESM-3 protein models capture similar biology because they called the finding cool and the summarization great.

4 comments with sentiment.

113625959.4K

Cluster engagement

23 snapshots