CrystalBoltz Uses Experiment-Guided Diffusion for End-to-End X-Ray Structure Determination

AlphaFold-like models such as Boltz-2 and AlphaFold3 learn powerful priors over structures from PDB. But how can we make them aware of new X-ray crystallography data? Introducing CrystalBoltz: end-to-end X-ray structure determination via experiment-guided diffusion. 1/4 🧵