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Claude reportedly finds a previously unknown enzyme system in bacteriophage DNA

Anthropic calls it the first result from its new molecular biology lab. Nearby DNA repeats look somewhat like CRISPR, the company says, but the system’s function is still unknown.

AnthropicAN
Gary MarcusGM
Tanishq Mathew Abraham, Ph.D.TM
13 Sources, 20d ago, first seen 20d ago

TLDR

Anthropic says Claude found the system in bacteriophages—viruses that infect bacteria—with a long array of repeating DNA beside the enzyme’s gene. The company cautions that much more work is needed to learn what the system does and whether it could have uses similar to CRISPR.

Anthropic describes a division of work at its new molecular biology lab: Claude explores data and literature to generate hypotheses, while scientists review the ideas, test the most promising ones and perform all lab work.

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13 Sources, first seen 20d ago

4.8K likes165 comments772 saves2.1K reposts

Combined views

935.1K

13 Sources, first seen 20d ago

4.8K likes165 comments772 saves2.1K reposts

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13 Sources

Anthropic@AnthropicAIThis is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.20d
Rohan Paul@rohanpaul_aiJUST IN: Anthropic’s new wet lab has made its first discovery, as nearly 950 Claude agents independently found a new enzyme after 21 hours of work. - per TheVerge Anthropic told The Verge that nearly 950 Claude agents worked for 21 hours, consuming 210 million tokens, before an agent noticed an unusual repeating DNA pattern. Subsequent analysis and wet-lab testing identified what Anthropic called “a previously uncharacterized enzyme system found in bacteriophages.”20d
Dr Singularity@Dr_SingularityFirst math. Now we’re starting to see similar acceleration in biology. it was fast... AI is starting to make big biological discoveries Anthropic says Claude autonomously discovered a previously uncharacterized enzyme system with CRISPR like DNA repeats while searching massive genomic databases. Around 950 Claude agents worked for 21 hours, analyzed more than 200,000 reverse transcriptases, generated 1000s of candidates, and surfaced a system human researchers then validated experimentally. The function of the new system, called ART, is still being investigated, but its architecture resembles other programmable biological systems capable of manipulating genetic information. If this kind of AI driven genome mining scales, it could compress weeks or months of expert research into hours. 👀 "This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields" 1000s x acceleration incoming. because of that aging reversal therapies are near (2030s)20d
Jack | amatica health@JackHadfield14Simplified: Claude scanned a huge DNA database and found a new enzyme system hiding in viruses that infect bacteria. Its DNA has a repeating pattern that looks like CRISPR, the tool scientists use to edit DNA. What it actually does is still unknown, and lab tests are ongoing.20d
vittorio@IterIntellectusthis is absolutely incredible we are watching AI begin to discover entirely new biological systems that humans didn’t even know existed. AI is actually expanding the frontier of biology itself. once again, this is the age of biotech.20d
Tanishq Mathew Abraham, Ph.D.@iScienceLuvrIt's kinda wild to see LLMs having this sort of "a-ha"/lightbulb moment in the biological setting!!20d
The Circuitry@thecircuitry_Anthropic says Claude autonomously discovered a new enzyme system comparable to Crispr's gene-editing machinery after scanning a large DNA database. Scientists limited their role to the initial prompt and subsequent lab work.20d
Tenobrus@tenobrusas far as i can tell, as a non-expert, this is basically "not a big result". it's maybe like an interesting thing for a bio PhD student to have discovered in the early stage of their thesis. which is... about where ai was for math with erdos problems around last december. please please please please please please stop ignoring trendlines20d
Gary Marcus@GaryMarcusRT @at_fome: I work in CRISPR discovery research. This is one of the most exaggerated nothing-burgers ever and would be laughed out of the…19d
Aran Nayebi@aran_nayebiRT @8teAPi: This whole fiasco is reminiscent of the early days of Erdos math. Less than a year ago. The first discoveries were “well that…18d
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    13 Sources

    Anthropic@AnthropicAIThis is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.20d
    Rohan Paul@rohanpaul_aiJUST IN: Anthropic’s new wet lab has made its first discovery, as nearly 950 Claude agents independently found a new enzyme after 21 hours of work. - per TheVerge Anthropic told The Verge that nearly 950 Claude agents worked for 21 hours, consuming 210 million tokens, before an agent noticed an unusual repeating DNA pattern. Subsequent analysis and wet-lab testing identified what Anthropic called “a previously uncharacterized enzyme system found in bacteriophages.”20d
    Dr Singularity@Dr_SingularityFirst math. Now we’re starting to see similar acceleration in biology. it was fast... AI is starting to make big biological discoveries Anthropic says Claude autonomously discovered a previously uncharacterized enzyme system with CRISPR like DNA repeats while searching massive genomic databases. Around 950 Claude agents worked for 21 hours, analyzed more than 200,000 reverse transcriptases, generated 1000s of candidates, and surfaced a system human researchers then validated experimentally. The function of the new system, called ART, is still being investigated, but its architecture resembles other programmable biological systems capable of manipulating genetic information. If this kind of AI driven genome mining scales, it could compress weeks or months of expert research into hours. 👀 "This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields" 1000s x acceleration incoming. because of that aging reversal therapies are near (2030s)20d
    Jack | amatica health@JackHadfield14Simplified: Claude scanned a huge DNA database and found a new enzyme system hiding in viruses that infect bacteria. Its DNA has a repeating pattern that looks like CRISPR, the tool scientists use to edit DNA. What it actually does is still unknown, and lab tests are ongoing.20d
    vittorio@IterIntellectusthis is absolutely incredible we are watching AI begin to discover entirely new biological systems that humans didn’t even know existed. AI is actually expanding the frontier of biology itself. once again, this is the age of biotech.20d
    Tanishq Mathew Abraham, Ph.D.@iScienceLuvrIt's kinda wild to see LLMs having this sort of "a-ha"/lightbulb moment in the biological setting!!20d
    The Circuitry@thecircuitry_Anthropic says Claude autonomously discovered a new enzyme system comparable to Crispr's gene-editing machinery after scanning a large DNA database. Scientists limited their role to the initial prompt and subsequent lab work.20d
    Tenobrus@tenobrusas far as i can tell, as a non-expert, this is basically "not a big result". it's maybe like an interesting thing for a bio PhD student to have discovered in the early stage of their thesis. which is... about where ai was for math with erdos problems around last december. please please please please please please stop ignoring trendlines20d
    Gary Marcus@GaryMarcusRT @at_fome: I work in CRISPR discovery research. This is one of the most exaggerated nothing-burgers ever and would be laughed out of the…19d
    Aran Nayebi@aran_nayebiRT @8teAPi: This whole fiasco is reminiscent of the early days of Erdos math. Less than a year ago. The first discoveries were “well that…18d
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