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    ARPA-H’s clinical trial push reportedly aims to cut timelines from 10-plus years to under four

    A commentator says adaptive trials could speed decisions on drugs, while digital twins could reduce reliance on large control groups.

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    TLDR

    ARPA-H shared an “Advancing Clinical Trials” announcement. A commentator says its plan aims to cut trial times from 10-plus years to under four through adaptive “phaseless” trials, digital-twin simulations, AI agents for trial operations and reusable trial sites at ordinary hospitals. The commentator says the simulations could reduce reliance on large control groups, while AI could flag eligible trials to doctors and patients.

    Combined views

    35.9K

    2 Sources, first seen 12h ago

    Combined views

    35.9K

    2 Sources, first seen 12h ago

    388 likes
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    12h ago
    first seen 12h ago
    388 likes
    16 comments
    262 saves
    107 reposts
    Featured Source
    16 comments
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    107 reposts

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    Positive——Negative

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    2 Sources

    @DrSamuelBHumeHow ARPA-H is planning to cut clinical trial times from 10+ years to <4 years: 1. 'Phaseless' clinical trials - move towards replacing phase 1 → 2 → 3 with adaptive trials that can cut failed drugs (or advance good ones) faster. 2. Simulate trial outcomes before starting, with digital twins - to reduce reliance on large control groups. 3. AI agents for trial operations. 4. Turn ordinary hospitals into reusable clinical trial sites, and gets AIs to flag eligible trials to doctors and patients.
    @chr1saRT @DrSamuelBHume: How ARPA-H is planning to cut clinical trial times from 10+ years to <4 years: 1. 'Phaseless' clinical trials - move to…

    Sentiment

    Positive——Negative

    Summary

    Not enough discussion yet.

    No sentiment analysis available yet.

    2 Sources

    @DrSamuelBHumeHow ARPA-H is planning to cut clinical trial times from 10+ years to <4 years: 1. 'Phaseless' clinical trials - move towards replacing phase 1 → 2 → 3 with adaptive trials that can cut failed drugs (or advance good ones) faster. 2. Simulate trial outcomes before starting, with digital twins - to reduce reliance on large control groups. 3. AI agents for trial operations. 4. Turn ordinary hospitals into reusable clinical trial sites, and gets AIs to flag eligible trials to doctors and patients.
    @chr1saRT @DrSamuelBHume: How ARPA-H is planning to cut clinical trial times from 10+ years to <4 years: 1. 'Phaseless' clinical trials - move to…